Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 3/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.44 |
| ▸ | GABRE | P78334 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.44 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.44 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL104705 | 0.85 | LMNA (0.37) | GABRA5GABRA1TSHRGABRG2GABRB3 | |
| Hydrochloric Acid SCHEMBL2253109 | 0.83 | MEN1 (0.35) | GABRA5GABRA1TSHRGABRG2GABRB3 | |
| Formic Acid SCHEMBL28915413 | 0.82 | LIPA (0.35) | GABRA5GABRA1TSHRGABRG2GABRB3 | |
| Formic Acid SCHEMBL28915063 | 0.80 | LIPA (0.34) | GABRA5GABRA1TSHRGABRG2GABRB3 | |
| Acetic Acid SCHEMBL10487370 | 0.79 | GABRA5 (0.39) | GABRA5GABRA1TSHRGABRG2GABRB3 | |
| SCHEMBL8873859 | 0.77 | GABRA5 (0.44) | GABRA5GABRA1TSHRGABRG2GABRB3 | |
| SCHEMBL12928717 | 0.77 | GABRA5 (0.39) | GABRA5GABRA1TSHRGABRG2GABRB3 | |
| SCHEMBL15910211 | 0.77 | GABRA5 (0.44) | GABRA5GABRA1TSHRGABRG2GABRB3 | |
| Acetic Acid SCHEMBL4353702 | 0.76 | EPHX1 (0.53) | CYP2D6LMNAMEN1KMT2AEPHX1 | |
| SCHEMBL22142244 | 0.76 | MEN1 (0.32) | CYP2D6LMNAMEN1HRH1SCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119350297-B | Specific lysosome targeting chimeric molecule and preparation method and application thereof | 浙江大学 | 2025-04-04 | — | — | CN | disclosed |
| CN-119350297-A | Specific lysosome targeting chimeric molecule and preparation method and application thereof | 浙江大学 | 2025-01-24 | — | — | CN | disclosed |