Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 17/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 6/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3136093 | 0.85 | DPP4 (0.39) | DPP4DPP8DPP7DPP9 | |
| SCHEMBL8270606 | 0.82 | SCN9A (0.43) | DPP4DPP8DPP7DPP9 | |
| SCHEMBL4489140 | 0.73 | DPP4 (0.41) | DPP4DPP8DPP7DPP9 | |
| SCHEMBL10054446 | 0.73 | MMEL1 (0.42) | DPP4DPP8DPP7DPP9MAPK8 | |
| SCHEMBL18262776 | 0.72 | MME (0.54) | MMEMMEL1 | |
| SCHEMBL18262773 | 0.72 | MME (0.54) | MMEMMEL1 | |
| SCHEMBL1509219 | 0.70 | CTSS (0.45) | DPP4DPP8DPP7DPP9MME | |
| SCHEMBL2364410 | 0.70 | CTSS (0.45) | DPP4DPP8DPP7DPP9MME | |
| SCHEMBL10054447 | 0.70 | CTSS (0.45) | DPP4DPP8DPP7DPP9MME | |
| SCHEMBL5813062 | 0.70 | DPP4 (0.46) | DPP4DPP8DPP7DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784188-B1 | FUSED TRIAZOLE DERIVATIVES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME (US) | 2010-07-14 | — | — | EP | disclosed |