SCHEMBL3136774

SCHEMBL3136774

CCCCCCn1c(S)nc2cc(Cl)ccc21

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 4/20 0.49
BACE1 P56817 2/20 0.49
NUDT1 P36639 1/20 0.49
PSEN1 P49768 6/20 0.48
PSEN2 P49810 6/20 0.48
APH1B Q8WW43 6/20 0.48
NCSTN Q92542 6/20 0.48
APH1A Q96BI3 6/20 0.48
PSENEN Q9NZ42 6/20 0.48
KMT2A Q03164 1/20 0.48
TP53 P04637 2/20 0.41
MAPT P10636 1/20 0.41
ENPP2 Q13822 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8381209 0.82 KMT2A (0.51) BACE1NUDT1KMT2ATP53MAPT
SCHEMBL3146129 0.81 TDP1 (0.53) TLR8TP53MAPT
SCHEMBL3141446 0.80 TLR8 (0.68) TLR8TP53MAPT
SCHEMBL10833410 0.80 TLR8 (0.68) TLR8TP53MAPT
SCHEMBL3136462 0.80 TLR8 (0.68) TLR8TP53MAPT
SCHEMBL15382597 0.80 TLR8 (0.68) TLR8TP53MAPT
SCHEMBL11688692 0.78 BACE1 (0.50) BACE1NUDT1KMT2A
SCHEMBL3137088 0.78 TLR8 (0.68) TLR8TP53MAPT
SCHEMBL22777751 0.76 BACE1 (0.50) TLR8BACE1NUDT1KMT2ATP53
SCHEMBL12730935 0.75 KMT2A (0.48) BACE1NUDT1KMT2ATP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8714088-B2 Lithographic printing plate precursor and lithographic printing method FUJIFILM CORPORATION (JP) 2014-05-06 US disclosed
US-8304171-B2 Plate making method of lithographic printing plate precursor FUJIFILM CORPORATION (JP) 2012-11-06 US disclosed
US-20100075260-A1 PLATE MAKING METHOD OF LITHOGRAPHIC PRINTING PLATE PRECURSOR FUJIFILM CORPORATION (JP) 2010-03-25 US disclosed
US-20090246700-A1 PLATE-MAKING METHOD OF LITHOGRAPHIC PRINTING PLATE PRECURSOR FUJIFILM CORPORATION (JP) 2009-10-01 US disclosed
US-20090246699-A1 PLATE-MAKING METHOD OF LITHOGRAPHIC PRINTING PLATE PRECURSOR FUJIFILM CORPORATION (JP) 2009-10-01 US disclosed
EP-2090933-A1 Lithographic printing plate precursor and printing method FUJIFILM Corporation (JP) 2009-08-19 EP disclosed
US-20090197205-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AND PRINTING METHOD FUJIFILM CORPORATION (JP) 2009-08-06 US disclosed
US-20090114108-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AND LITHOGRAPHIC PRINTING METHOD FUJIFILM CORPORATION (JP) 2009-05-07 US disclosed