Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUAK1 | O60285 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 9/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3130134 | 0.82 | NUAK1 (0.75) | NUAK1NTRK1IGF1R | |
| SCHEMBL3124569 | 0.81 | NTRK1 (0.55) | NUAK1NTRK1IGF1R | |
| SCHEMBL3124562 | 0.81 | NTRK1 (0.55) | NUAK1NTRK1IGF1R | |
| SCHEMBL3137646 | 0.72 | NTRK1 (0.57) | NUAK1NTRK1 | |
| SCHEMBL3136376 | 0.72 | NTRK1 (0.57) | NUAK1NTRK1 | |
| SCHEMBL3133559 | 0.72 | NTRK1 (0.55) | NUAK1NTRK1 | |
| SCHEMBL3133566 | 0.72 | NTRK1 (0.55) | NUAK1NTRK1 | |
| SCHEMBL3136390 | 0.72 | NTRK1 (0.57) | NUAK1NTRK1 | |
| SCHEMBL27710919 | 0.72 | NUAK1 (0.51) | NUAK1NTRK1IGF1R | |
| SCHEMBL2490728 | 0.72 | NTRK1 (0.64) | NUAK1NTRK1DYRK1ADYRK2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853602-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-07-14 | — | — | EP | disclosed |