Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUAK1 | O60285 | 1/20 | 0.75 |
| ▸ | NTRK1 | P04629 | 9/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | STK4 | Q13043 | 1/20 | 0.43 |
| ▸ | STK3 | Q13188 | 1/20 | 0.43 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.43 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.43 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3127355 | 0.87 | NUAK1 (0.73) | NUAK1NTRK1IGF1R | |
| SCHEMBL3127453 | 0.87 | NUAK1 (0.84) | NUAK1NTRK1IGF1R | |
| SCHEMBL3136977 | 0.86 | NUAK1 (1.00) | NUAK1NTRK1IGF1R | |
| SCHEMBL3136840 | 0.82 | NUAK1 (0.54) | NUAK1NTRK1IGF1R | |
| SCHEMBL3137646 | 0.79 | NTRK1 (0.57) | NUAK1NTRK1 | |
| SCHEMBL3136390 | 0.79 | NTRK1 (0.57) | NUAK1NTRK1 | |
| SCHEMBL27710919 | 0.79 | NUAK1 (0.51) | NUAK1NTRK1IGF1RPAK1 | |
| SCHEMBL3136376 | 0.79 | NTRK1 (0.57) | NUAK1NTRK1 | |
| SCHEMBL3132279 | 0.79 | NTRK1 (0.50) | NUAK1NTRK1 | |
| SCHEMBL3132518 | 0.79 | NUAK1 (0.51) | NUAK1NTRK1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853602-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-07-14 | — | — | EP | disclosed |