Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12166934 | 1.00 | TPMT (0.42) | TPMTALOX15TSHRHIF1ASMN1; SMN2 | |
| SCHEMBL10949551 | 0.88 | ALOX15 (0.46) | TPMTALOX15TSHRHIF1ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10573659 | 0.86 | ALOX15 (0.45) | TPMTALOX15TSHRHIF1ASMN1; SMN2 | |
| SCHEMBL1348688 | 0.84 | POLB (0.40) | SMN1; SMN2ALDH1A1LMNAHTTCA12 | |
| SCHEMBL1498369 | 0.80 | GPBAR1 (0.47) | SMN1; SMN2RAB9ALCKFYNALDH1A1 | |
| SCHEMBL1179149 | 0.80 | TPMT (0.56) | TPMTALOX15TSHRHIF1ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1179035 | 0.78 | TPMT (0.54) | TPMTALOX15TSHRHIF1ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11078337 | 0.78 | TPMT (0.54) | TPMTALOX15TSHRHIF1ASMN1; SMN2 | |
| SCHEMBL3439357 | 0.77 | KDM4E (0.51) | TPMTALOX15TSHRHIF1ASMN1; SMN2 | |
| SCHEMBL24773614 | 0.76 | LMNA (0.36) | ALOX15TSHRHIF1ASMN1; SMN2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739685-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008061-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |