Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 9/20 | 0.42 |
| ▸ | CCND1 | P24385 | 4/20 | 0.42 |
| ▸ | CDK1 | P06493 | 3/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.42 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 2/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3138726 | 0.89 | CCNA2 (0.43) | CDK4CCND1CDK1CDK6CCNE1 | |
| SCHEMBL3137902 | 0.88 | CDK6 (0.49) | CDK4CCND1CDK1FLT3CDK6 | |
| Hydrochloric Acid SCHEMBL3147026 | 0.88 | CCNA2 (0.42) | CDK4CCND1CDK1CDK6CCNE1 | |
| SCHEMBL3128560 | 0.88 | CCNA2 (0.44) | CDK4CCND1CDK6NPC1MAPT | |
| Hydrochloric Acid SCHEMBL3158986 | 0.87 | CDK6 (0.48) | CDK4CCND1CDK1FLT3CDK6 | |
| Hydrochloric Acid SCHEMBL3143181 | 0.87 | CCNA2 (0.44) | CDK4CCND1CDK6NPC1MAPT | |
| SCHEMBL3137946 | 0.86 | CYP1A1 (0.48) | CDK4CCND1CDK6NPC1GAA | |
| Hydrochloric Acid SCHEMBL3134638 | 0.85 | CYP1A1 (0.47) | CDK4CCND1CDK6NPC1GAA | |
| Hydrochloric Acid SCHEMBL6368427 | 0.81 | SLC2A1 (0.60) | NPC1MAPTRAB9ASMN1; SMN2SLC2A1 | |
| SCHEMBL2820000 | 0.78 | TRPM8 (0.55) | MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742935-B1 | POLYCYCLIC PYRAZINES AS POTASSIUM ION CHANNEL MODULATORS | ICAGEN INC (US) | 2010-02-24 | — | — | EP | claimed |
| US-7642354-B2 | Use treating nervous system disorders, as neuroprotectants, gastrointestinal disorders, cardiovascular disorders; e.g. 2-(5-phenylpyridin-2-ylamino)-6-pyridin-2-ylpyrimidine | ICAGEN, INC. (US) | 2010-01-05 | — | — | US | claimed |
| EP-1742935-B1 | POLYCYCLIC PYRAZINES AS POTASSIUM ION CHANNEL MODULATORS | ICAGEN INC (US) | 2010-02-24 | — | — | EP | disclosed |