SCHEMBL31374641

SCHEMBL31374641

COc1cc(OC)cc(-c2ccccc2C#N)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 2/20 0.58
ABCB1 P08183 2/20 0.58
BCR P11274 2/20 0.58
GAA P10253 2/20 0.49
POLB P06746 1/20 0.49
ESR2 Q92731 1/20 0.49
ADORA2A P29274 3/20 0.46
ADORA2B P29275 3/20 0.46
ADORA1 P30542 2/20 0.46
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
GLA P06280 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
CYP1A1 P04798 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2E1 P05181 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2C8 P10632 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2A6 P11509 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9469502 0.86 ALDH1A1 (0.57) GAAADORA2AADORA2BADORA1KDM4E
SCHEMBL6951995 0.84 ESR2 (0.59) ABL1ABCB1BCRGAAPOLB
SCHEMBL22001145 0.82 ABL1 (0.46) ABL1ABCB1BCRGAAPOLB
SCHEMBL20282675 0.76 POLB (0.54) ABL1ABCB1BCRGAAPOLB
SCHEMBL28133054 0.76 ESR2 (0.53) GAAESR2KDM4EALDH1A1CYP1A2
SCHEMBL29662936 0.76 ESR2 (0.53) GAAESR2KDM4EALDH1A1CYP1A2
SCHEMBL2533391 0.74 AR (0.50) ABL1ABCB1BCRGAAKDM4E
SCHEMBL28802576 0.74 MAOA (0.49) GAAPOLBADORA2AADORA1ALDH1A1
SCHEMBL12672619 0.73 AR (0.55) ESR2KDM4EALDH1A1CYP1A2CYP3A4
SCHEMBL15832019 0.73 AR (0.44) ABL1ABCB1BCRGAAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119451699-A Medicine for combined use 中外制药株式会社 2025-02-14 CN disclosed