Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LATS1 | O95835 | 16/20 | 0.42 |
| ▸ | LATS2 | Q9NRM7 | 11/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKCH | P24723 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24174998 | 0.77 | NCF1 (0.59) | LATS1LATS2KDM4EPOLBHTT | |
| SCHEMBL26424915 | 0.72 | MCHR1 (0.44) | KDM4EPOLBHTTLMNAACHE | |
| SCHEMBL24506782 | 0.71 | HSD17B10 (0.35) | KDM4E | |
| SCHEMBL29650635 | 0.71 | LATS1 (0.56) | LATS1LATS2ACHE | |
| SCHEMBL13249607 | 0.69 | MAP4K4 (0.39) | LATS1LATS2POLBHTTIMPDH2 | |
| SCHEMBL4246335 | 0.69 | ACHE (0.70) | LATS1LATS2KDM4EPOLBHTT | |
| SCHEMBL13666782 | 0.68 | LATS1 (0.36) | LATS1LATS2ROCK2PRKCHPRKCQ | |
| SCHEMBL26795820 | 0.68 | LATS1 (0.36) | LATS1LATS2KDM4EHTTROCK2 | |
| SCHEMBL31375899 | 0.68 | LATS1 (0.59) | LATS1LATS2KDM4EPOLBHTT | |
| SCHEMBL31375147 | 0.67 | LATS1 (0.60) | LATS1LATS2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114621222-B | 6-6 Fused bicyclic heteroaryl compounds and their use as LATS inhibitors | 诺华股份有限公司 | 2024-12-17 | — | — | CN | disclosed |