SCHEMBL31377136

SCHEMBL31377136

COC(=O)c1ccc2onc(NC(=O)OC(C)(C)C)c2c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 4/20 0.44
SMN1; SMN2 Q16637 4/20 0.44
MAPT P10636 2/20 0.44
HIF1A Q16665 1/20 0.43
STK17B O94768 1/20 0.40
LCK P06239 3/20 0.39
ATR Q13535 1/20 0.39
CA12 O43570 2/20 0.39
CA1 P00915 2/20 0.39
CA9 Q16790 2/20 0.39
CA2 P00918 1/20 0.39
CA7 P43166 1/20 0.39
XDH P47989 1/20 0.39
CA14 Q9ULX7 1/20 0.39
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
KDM4E B2RXH2 2/20 0.38
GABRA1 P14867 1/20 0.38
GABRG2 P18507 1/20 0.38
GABRB3 P28472 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31377141 0.89 TP53 (0.42) TP53SMN1; SMN2MAPTSTK17BLCK
SCHEMBL21240884 0.84 MAPT (0.46) TP53SMN1; SMN2MAPTSTK17BLCK
SCHEMBL30682021 0.82 MAP4K4 (0.41) TP53SMN1; SMN2MAPTSTK17BLCK
SCHEMBL2145260 0.82 ALDH1A1 (0.42) TP53SMN1; SMN2MAPTSTK17BLCK
SCHEMBL3737669 0.80 CYP17A1 (0.39) TP53SMN1; SMN2MAPTSTK17BCA12
SCHEMBL12636152 0.79 TP53 (0.55) TP53SMN1; SMN2MAPTHIF1ANPC1
SCHEMBL17202831 0.79 TP53 (0.42) TP53SMN1; SMN2MAPTLCKCA12
SCHEMBL23926517 0.78 TP53 (0.61) TP53SMN1; SMN2MAPTHIF1ACA12
SCHEMBL6990569 0.78 CA12 (0.44) HIF1ACA12CA1CA9CA2
SCHEMBL25678133 0.76 CA12 (0.45) TP53SMN1; SMN2MAPTLCKCA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025064683-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS Interdict Bio, Inc. (US) 2025-03-27 WO disclosed
US-20250091989-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS Interdict Bio, Inc. (US) 2025-03-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250091989-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS MYC, KRAS, NRAS TP53 26/4885SMN1; SMN2 1694/4885MAPT 2060/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.