⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14853364 | 0.81 | AVPR1A (0.31) | — | |
| SCHEMBL14123381 | 0.78 | — | — | |
| SCHEMBL31378657 | 0.78 | NOS3 (0.31) | — | |
| SCHEMBL31378849 | 0.78 | NOS3 (0.31) | — | |
| SCHEMBL18869667 | 0.76 | — | — | |
| SCHEMBL13544036 | 0.76 | ALDH1A1 (0.35) | — | |
| SCHEMBL31378895 | 0.76 | — | — | |
| SCHEMBL6776899 | 0.76 | MAPK1 (0.34) | — | |
| SCHEMBL15759117 | 0.73 | HSD17B10 (0.31) | — | |
| SCHEMBL14192075 | 0.72 | MAPT (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250171431-A1 | HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE | HORIZON THERAPEUTICS IRELAND DAC (IE) | 2025-05-29 | — | — | US | disclosed |
| WO-2025030163-A1 | HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE | HORIZON THERAPEUTICS IRELAND DAC (IE) | 2025-02-06 | — | — | WO | disclosed |