SCHEMBL31379545

SCHEMBL31379545

Oc1cc(Cl)c(F)cc1I

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.40
HSD17B10 Q99714 5/20 0.40
HPGD P15428 3/20 0.40
ALDH1A1 P00352 4/20 0.39
TDP1 Q9NUW8 2/20 0.39
CYP3A4 P08684 2/20 0.37
HSP90AA1 P07900 2/20 0.37
MAPT P10636 2/20 0.35
ERCC1 P07992 1/20 0.33
ERCC4 Q92889 1/20 0.33
KDM1A O60341 2/20 0.31
MEN1 O00255 1/20 0.31
HTT P42858 1/20 0.31
KMT2A Q03164 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
KDM1B Q8NB78 1/20 0.31
PIK3CA P42336 2/20 0.31
CA3 P07451 1/20 0.31
CA6 P23280 1/20 0.31
CA5A P35218 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1093924 1.00 TSHR (0.40) TSHRHSD17B10HPGDALDH1A1TDP1
SCHEMBL1094353 0.91 ALDH1A1 (0.39) TSHRHSD17B10HPGDALDH1A1TDP1
SCHEMBL5785240 0.79 HSD17B10 (0.55) TSHRHSD17B10HPGDALDH1A1TDP1
SCHEMBL18894055 0.79 CA9 (0.36) HSD17B10TDP1CYP3A4HSP90AA1MAPT
SCHEMBL30525059 0.77 ALDH1A1 (0.43) ALDH1A1TDP1MAPTKDM1AMEN1
SCHEMBL911775 0.77 TSHR (0.60) TSHRHSD17B10HPGDALDH1A1TDP1
SCHEMBL31357885 0.77 TSHR (0.60) TSHRHSD17B10HPGDALDH1A1TDP1
SCHEMBL926241 0.77 ALDH1A1 (0.43) ALDH1A1TDP1MAPTKDM1AMEN1
SCHEMBL22560903 0.77 HSD17B10 (0.46) TSHRHSD17B10HPGDALDH1A1TDP1
SCHEMBL27047975 0.77 CA3 (0.35) HSP90AA1CA3CA6CA5ACA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025036241-A1 COMPOUNDS AND METHODS FOR MODULATING RNA SPLICING RIBOPEUTIC INC. (CN) 2025-02-20 WO disclosed