Known targets — ChEMBL curated mechanism
CSF1RFLT1FLT3FLT4KDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | APP | P05067 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.66 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.66 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.46 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL810935 | 1.00 | ALDH1A1 (0.66) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacinamide SCHEMBL580180 | 0.88 | F7 (0.65) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacinamide SCHEMBL29011862 | 0.88 | F7 (0.65) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Malic Acid SCHEMBL28810369 | 0.88 | ALDH1A1 (0.49) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL810760 | 0.84 | ALDH1A1 (0.57) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Cadaverine Tartrate SCHEMBL219351 | 0.82 | ALDH1A1 (0.78) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Malic Acid SCHEMBL7300885 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2KMONAPRT | |
| Niacin SCHEMBL811046 | 0.81 | LMNA (0.61) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL1433 | 0.81 | — | — | |
| Niacin SCHEMBL3081560 | 0.81 | ALDH1A1 (1.00) | ALDH1A1APPGAAHCAR3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119699489-A | Feed for white-feather parent breeding ducks and preparation process thereof | 潍坊中基饲料有限公司 | 2025-03-28 | — | — | CN | claimed |
| CN-119699489-A | Feed for white-feather parent breeding ducks and preparation process thereof | 潍坊中基饲料有限公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-119699489-A | Feed for white-feather parent breeding ducks and preparation process thereof | 潍坊中基饲料有限公司 | 2025-03-28 | — | — | CN | disclosed |