Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | BRPF1 | P55201 | 3/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 3/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3135299 | 0.80 | HTT (0.45) | DAOKMT2ALMNASMN1; SMN2MAPT | |
| SCHEMBL13757029 | 0.77 | DAO (0.53) | DAOBRPF1AHRKDM4EKMT2A | |
| SCHEMBL13478600 | 0.77 | DAO (0.59) | DAOBRPF1AHRHCRTR1HCRTR2 | |
| SCHEMBL347390 | 0.72 | MAPT (0.59) | KDM4EIMPDH2LMNAIMPDH1MAPT | |
| SCHEMBL30839714 | 0.72 | MAPT (0.59) | KDM4EIMPDH2LMNAIMPDH1MAPT | |
| SCHEMBL3685492 | 0.72 | BRD4 (0.43) | KDM4EKMT2ABRD4IMPDH2LMNA | |
| SCHEMBL18537222 | 0.72 | AHR (0.56) | DAOAHRKDM4EKMT2A | |
| SCHEMBL3127507 | 0.72 | NCOA1 (0.59) | KDM4EKMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL29496272 | 0.71 | DAO (0.46) | DAOBRPF1AHRKDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL10604756 | 0.71 | MAPT (0.57) | KDM4EKMT2AIMPDH2LMNAIMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021333-B1 | ANTI-PROLIFERATIVE COMPOUNDS DERIVING FROM A 3-ARYL-COUMARINE OR 3-ARYL-QUINOLIN-2-ONE AND USES THEREOF | EOS ETHICAL ONCOLOGY SCIENCE S (IT) | 2010-07-14 | — | — | EP | disclosed |
| US-20090203685-A1 | ANTI-PROLIFERATIVE COMPOUNDS FROM A 3-ARYL-COUMARINE OR 3-ARYL-QUINOLIN-2-ONE AND USES THEREOF | EOS (ETHICAL ONCOLOGY SCIENCE) S.P.A. (IT) | 2009-08-13 | — | — | US | disclosed |
| US-20090203685-A1 | ANTI-PROLIFERATIVE COMPOUNDS FROM A 3-ARYL-COUMARINE OR 3-ARYL-QUINOLIN-2-ONE AND USES THEREOF | EOS (ETHICAL ONCOLOGY SCIENCE) S.P.A. (IT) | 2009-08-13 | — | — | US | disclosed |
| US-20090203685-A1 | ANTI-PROLIFERATIVE COMPOUNDS FROM A 3-ARYL-COUMARINE OR 3-ARYL-QUINOLIN-2-ONE AND USES THEREOF | EOS (ETHICAL ONCOLOGY SCIENCE) S.P.A. (IT) | 2009-08-13 | — | — | US | disclosed |
| EP-2021333-A2 | ANTI-PROLIFERATIVE COMPOUNDS DERIVING FROM A 3-ARYL-COUMARINE OR 3-ARYL-QUINOLIN-2-ONE AND USES THEREOF | EOS - Ethical Oncology Science S.p.A. (IT) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007135565-A2 | ANTI-PROLIFERATIVE COMPOUNDS DERIVING FROM A 3-ARYL-COUMARINE OR 3-ARYL-QUINOLIN-2-ONE AND USES THEREOF | EOS (ETHICAL ONCOLOGY SCIENCE) S.P.A. (IT) | 2007-11-29 | — | — | WO | disclosed |
| WO-2007135565-A2 | ANTI-PROLIFERATIVE COMPOUNDS DERIVING FROM A 3-ARYL-COUMARINE OR 3-ARYL-QUINOLIN-2-ONE AND USES THEREOF | EOS (ETHICAL ONCOLOGY SCIENCE) S.P.A. (IT) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203685-A1 | ANTI-PROLIFERATIVE COMPOUNDS FROM A 3-ARYL-COUMARINE OR 3-ARYL-QUINOLIN-2-ONE AND USES THEREOF | MKI67, CCNA1, CCNI | DAO 4030/4885BRPF1 3317/4885AHR 130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.