Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 12/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30983283 | 0.82 | HDAC1 (0.53) | HDAC1HDAC6CXCR4ADORA2AKCNH2 | |
| SCHEMBL31380390 | 0.78 | HDAC1 (0.55) | HDAC1HDAC6CXCR4ADORA2A | |
| SCHEMBL31324080 | 0.78 | HDAC1 (0.55) | HDAC1HDAC6CXCR4ADORA2A | |
| SCHEMBL30379489 | 0.77 | HDAC1 (0.61) | HDAC1HDAC6CXCR4ADORA2ASLC40A1 | |
| SCHEMBL31380305 | 0.75 | HDAC1 (0.48) | HDAC1HDAC6CXCR4ADORA2ASLC40A1 | |
| SCHEMBL4887341 | 0.75 | HDAC1 (0.69) | HDAC1HDAC6CXCR4 | |
| SCHEMBL4562865 | 0.75 | HDAC1 (0.69) | HDAC1HDAC6CXCR4 | |
| SCHEMBL13909820 | 0.74 | HDAC1 (0.76) | HDAC1HDAC6CXCR4 | |
| SCHEMBL31380322 | 0.74 | HDAC1 (0.51) | HDAC1HDAC6CXCR4GBA1 | |
| SCHEMBL30983240 | 0.74 | HDAC1 (0.51) | HDAC1HDAC6CXCR4GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025068985-A1 | 1-(1-OXO-1,2-DIHYDROPHTHALAZIN-6-YL)CYCLOALKYL-1-CARBOXAMIDE DERIVATIVES AS MTA-COOPERATIVE INHIBITORS OF PRMT5 | BEIGENE SWITZERLAND GMBH (CH) | 2025-04-03 | — | — | WO | disclosed |
| CN-119707931-A | Intermediate and synthesis method of 1- (1-oxo-1, 2-dihydro-phthalazin-6-yl) cycloalkyl-1-carboxamide derivatives as MTA synergistic inhibitors of PRMT5 | 百济神州(北京)生物科技有限公司 | 2025-03-28 | — | — | CN | disclosed |