SCHEMBL313815

SCHEMBL313815

COc1ccc([N+](=O)[O-])c(N)c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.68
ALDH1A1 P00352 6/20 0.68
LMNA P02545 2/20 0.68
TDP1 Q9NUW8 3/20 0.58
TSHR P16473 2/20 0.58
MAPK1 P28482 2/20 0.55
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
HTT P42858 3/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
GAA P10253 2/20 0.50
KDM4E B2RXH2 2/20 0.50
HPGD P15428 1/20 0.50
G6PD P11413 1/20 0.50
PKM P14618 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
RXFP1 Q9HBX9 1/20 0.50
APOBEC3G Q9HC16 1/20 0.50
THRB P10828 2/20 0.48
RECQL P46063 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31365106 1.00 MAPT (0.68) MAPTALDH1A1LMNATDP1TSHR
SCHEMBL5955457 0.90 ALDH1A1 (0.60) MAPTALDH1A1LMNATDP1TSHR
SCHEMBL11712245 0.89 ALDH1A1 (0.56) MAPTALDH1A1LMNATDP1TSHR
SCHEMBL4330380 0.86 MAPT (0.56) MAPTALDH1A1LMNATDP1TSHR
SCHEMBL204041 0.85 ALDH1A1 (0.61) MAPTALDH1A1LMNATDP1TSHR
SCHEMBL27774544 0.85 ALDH1A1 (0.61) MAPTALDH1A1LMNATDP1TSHR
SCHEMBL9195043 0.85 MAPT (0.67) MAPTALDH1A1LMNATDP1TSHR
SCHEMBL4969195 0.83 MAPT (0.50) MAPTALDH1A1LMNATDP1TSHR
SCHEMBL11404385 0.82 MAPT (0.52) MAPTALDH1A1LMNATDP1TSHR
SCHEMBL5956007 0.82 MAPT (0.52) MAPTALDH1A1LMNATDP1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 353 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117430967-A High-dispersity permanent orange RN and preparation method and application thereof 济宁阳光化学有限公司 2024-01-23 CN claimed
CN-115477654-B Near-infrared rhodamine dye with large Stokes displacement and synthesis method thereof 南宁师范大学 2023-08-22 CN claimed
CN-115477654-A Near-infrared rhodamine dye with high stability and large Stokes shift and synthetic method thereof 南宁师范大学 2022-12-16 CN claimed
CN-114539104-A Preparation method of Iguratimod intermediate 常州佳德医药科技有限公司 2022-05-27 CN claimed
CN-111875634-A Benzimidazole bidentate ligand-based luminescent copper compound and preparation method thereof 洛阳理工学院 2020-11-03 CN claimed
CN-111362867-A Mobile terminal, shell assembly, electrochromic material and preparation method thereof 宁波祢若电子科技有限公司 2020-07-03 CN claimed
US-9870909-B2 Compositions and methods for mass spectometry MSTM, LLC 2018-01-16 US claimed
US-20120053188-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF HYDROXAMIC ACID DERIVATIVES THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE(TGEN (US) 2012-03-01 US claimed
WO-2009100045-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF HYDROXAMIC ACID DERIVATIVES TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) 2009-08-13 WO claimed
EP-1172356-B1 Process for producing N-acylnitroaniline derivative SUMITOMO CHEMICAL CO (JP) 2004-10-06 EP claimed
US-6630598-B2 Reacting nitroaniline compound with acid chloride/anhydride in presence of alkali metal/earth metal compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-10-07 US claimed
US-20020016506-A1 Process for producing N-acylnitroaniline derivative SUMITOMO CHEMICAL COMPANY, LIMITED 2002-02-07 US claimed
EP-1172356-A1 Process for producing N-acylnitroaniline derivative SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-01-16 EP claimed
EP-4746965-A1 BENZIMIDAZOLES AS SIK-ACTIVITY MODULATORS F. Hoffmann-La Roche AG (CH) 2026-05-27 EP disclosed
US-20260042749-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2026-02-12 US disclosed
US-12545659-B2 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2026-02-10 US disclosed
EP-0071035-A1 Reactive mono-functional bisazo blue-black dye SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1983-02-09 EP disclosed
US-4185018-A Process for producing benzofurazan-1-oxides CIBA-GEIGY CORPORATION (US) 1980-01-22 US disclosed
US-3978038-A POLYAMIDES, POLYESTERS, POLYURETHANES CIBA-GEIGY CORPORATION (US) 1976-08-31 US disclosed
US-3953420-A Azo pigments derived from 2-hydroxy-3-carboxynaphthalene containing a substituted or unsubstituted phthalimide BADISCHE ANILIN- & SODA-FABRIK AKTIENGESELLSCHAFT (DT) 1976-04-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12545659-B2 IRAK degraders and uses thereof IRAK2, IRAK3, IRAK4 MAPT 3470/4885ALDH1A1 4348/4885LMNA 2896/4885
US-20120053188-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF HYDROXAMIC ACID DERIVATIVES HDAC5, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HDAC4 MAPT 4212/4885ALDH1A1 863/4885LMNA 1006/4885
US-20020016506-A1 Process for producing N-acylnitroaniline derivative NAAA, NAT1, ACOT7 MAPT 2912/4885ALDH1A1 824/4885LMNA 1607/4885
US-20260042749-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK4 MAPT 4151/4885ALDH1A1 3721/4885LMNA 3765/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.