Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29284702 | 0.78 | GAA (0.37) | GAAMGAMSIMGAM2MAPT | |
| SCHEMBL20545298 | 0.77 | MAPT (0.42) | GAAMAPTTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL29284712 | 0.77 | GAA (0.36) | ACHEGAAMGAMSIMGAM2 | |
| SCHEMBL29070863 | 0.75 | ACHE (0.44) | ACHEGAAMGAMSIMGAM2 | |
| SCHEMBL29284699 | 0.70 | GAA (0.38) | GAAMGAMSIMGAM2MAPT | |
| SCHEMBL8636289 | 0.68 | SLC6A3 (0.53) | ACHESLC6A3SLC6A2NPSR1 | |
| SCHEMBL28283233 | 0.66 | KDM4E (0.55) | GAAMGAMSIMGAM2MAPT | |
| SCHEMBL17702649 | 0.66 | KMT2A (0.51) | GAATSHRSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL13469340 | 0.66 | SLC6A3 (0.45) | ACHESMN1; SMN2SLC6A3SLC6A2 | |
| SCHEMBL4723143 | 0.65 | MEN1 (0.46) | GAAMGAMSIMGAM2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025045145-A1 | WRN HELICASE-INHIBITING BIS-HETEROCYCLIC DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | 广州科恩泰生物医药科技有限公司 | 2025-03-06 | — | — | WO | disclosed |
| CN-119528909-A | Bisheterocyclic derivative for inhibiting WRN helicase, pharmaceutical composition containing bisheterocyclic derivative and application of bisheterocyclic derivative | 上海科恩泰生物医药科技有限公司 | 2025-02-28 | — | — | CN | disclosed |