SCHEMBL31389658

SCHEMBL31389658

NC(=S)Nc1cccc(OC(F)(F)F)c1Br

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 2/20 0.47
▸ MAPT P10636 4/20 0.39
▸ ALDH1A1 P00352 4/20 0.39
▸ GAA P10253 3/20 0.39
▸ KDM4E B2RXH2 3/20 0.39
▸ MEN1 O00255 2/20 0.39
▸ KMT2A Q03164 2/20 0.39
▸ SMN1; SMN2 Q16637 2/20 0.39
▸ CYP1A2 P05177 2/20 0.38
▸ CYP3A4 P08684 2/20 0.38
▸ MAPK1 P28482 1/20 0.38
▸ GLA P06280 1/20 0.36
▸ RXFP1 Q9HBX9 1/20 0.36
▸ KCNK3 O14649 2/20 0.34
▸ KCNK9 Q9NPC2 2/20 0.34
▸ EGFR P00533 1/20 0.34
▸ IGF1R P08069 1/20 0.34
▸ MET P08581 1/20 0.34
▸ PDGFRB P09619 1/20 0.34
▸ KIT P10721 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30142030 0.84 L3MBTL1 (0.49) L3MBTL1MAPTALDH1A1GAAKDM4E
SCHEMBL5521725 0.84 L3MBTL1 (0.49) L3MBTL1MAPTALDH1A1GAAKDM4E
SCHEMBL17609898 0.83 L3MBTL1 (0.41) L3MBTL1MAPTALDH1A1GAAKDM4E
SCHEMBL31389431 0.78 EPHX1 (0.52) L3MBTL1MAPTALDH1A1KDM4EMEN1
SCHEMBL31389917 0.74 L3MBTL1 (0.56) L3MBTL1MAPTALDH1A1GAAKDM4E
SCHEMBL8436453 0.73 L3MBTL1 (0.71) L3MBTL1MAPTALDH1A1GAAKDM4E
SCHEMBL23043236 0.70 L3MBTL1 (0.56) L3MBTL1MAPTALDH1A1GAAKDM4E
SCHEMBL12804431 0.70 HPGD (0.43) L3MBTL1MAPTALDH1A1GAAKDM4E
SCHEMBL27972446 0.70 MPL (0.40) MAPTALDH1A1GAAKDM4ECYP3A4
SCHEMBL13712 0.69 GAA (0.55) MAPTALDH1A1GAAKDM4ERXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025043225-A2 DEGRADERS OF CYCLIN-DEPENDENT KINASE 2 GENENTECH, INC. (US) 2025-02-27 — — WO disclosed
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