Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.58 |
| ▸ | DDB1 | Q16531 | 12/20 | 0.58 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.38 |
| ▸ | GSPT1 | P15170 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | RXRB | P28702 | 2/20 | 0.35 |
| ▸ | RXRG | P48443 | 2/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25036702 | 0.90 | CRBN (0.57) | CRBNDDB1DGAT1SOAT1KDM4E | |
| SCHEMBL23541139 | 0.89 | DDB1 (0.64) | CRBNDDB1KDM4EALDH1A1MAPT | |
| SCHEMBL23842108 | 0.89 | DDB1 (0.72) | CRBNDDB1KDM4EALDH1A1MAPT | |
| SCHEMBL31397132 | 0.88 | CRBN (0.53) | CRBNDDB1GSPT1IKZF3 | |
| SCHEMBL25036546 | 0.86 | CRBN (0.58) | CRBNDDB1RXRARXRB | |
| SCHEMBL30273824 | 0.86 | CRBN (0.58) | CRBNDDB1RXRARXRB | |
| SCHEMBL24818103 | 0.83 | CRBN (0.70) | CRBNDDB1KDM4EALDH1A1MAPT | |
| SCHEMBL23540585 | 0.81 | CRBN (0.62) | CRBNDDB1GSPT1RXRARXRB | |
| SCHEMBL26094177 | 0.81 | CRBN (0.72) | CRBNDDB1IKZF3 | |
| SCHEMBL24821105 | 0.81 | CRBN (0.61) | CRBNDDB1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240424111-A1 | Degrader Compounds and Uses Thereof | CALICO LIFE SCIENCES LLC (US) | 2024-12-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240424111-A1 | Degrader Compounds and Uses Thereof | PTPN1, PTPN2, PTPN5 | CRBN 161/4885DDB1 2296/4885DGAT1 2323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.