Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 3/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | GPR183 | P32249 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31398585 | 1.00 | HSD11B1 (0.43) | HSD11B1GPR119HRH3HDAC2CHRNA7 | |
| SCHEMBL31398588 | 1.00 | HSD11B1 (0.43) | HSD11B1GPR119HRH3HDAC2CHRNA7 | |
| SCHEMBL1690779 | 0.82 | HSD11B1 (0.60) | HSD11B1GPR119HDAC2KMT2AHDAC1 | |
| SCHEMBL31398597 | 0.81 | HSD11B1 (0.47) | HSD11B1HDAC2CHRNA7KMT2AHDAC1 | |
| SCHEMBL31398596 | 0.81 | HSD11B1 (0.47) | HSD11B1HDAC2CHRNA7KMT2AHDAC1 | |
| SCHEMBL30094665 | 0.81 | HSD11B1 (0.51) | HSD11B1HDAC2CHRNA7KMT2AHDAC1 | |
| SCHEMBL12262158 | 0.78 | HSD11B1 (0.56) | HSD11B1GPR119HDAC2KMT2AHDAC1 | |
| SCHEMBL19029980 | 0.78 | GPR119 (0.45) | HSD11B1GPR119HRH3HDAC2HDAC1 | |
| SCHEMBL23024360 | 0.77 | HDAC2 (0.48) | HSD11B1GPR119HDAC2KMT2AHDAC1 | |
| SCHEMBL8152684 | 0.77 | USP2 (0.40) | GPR119KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4731613-A1 | SPIROCYCLIC PARP INHIBITORS AND METHODS OF USE | Valo Health, Inc. (US) | 2026-04-29 | — | — | EP | disclosed |
| WO-2024261710-A1 | SPIROCYCLIC PARP INHIBITORS AND METHODS OF USE | VALO HEALTH, INC. (US) | 2024-12-26 | — | — | WO | disclosed |