SCHEMBL31399012

SCHEMBL31399012

O=c1[nH]ccc2cc(Cl)cc(Cl)c12

nearest known ligand 0.54

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CHEK1 O14757 9/20 0.54
JAK2 O60674 2/20 0.46
RPS6KA3 P51812 1/20 0.46
MELK Q14680 1/20 0.46
STK24 Q9Y6E0 1/20 0.46
AHR P35869 3/20 0.42
F7 P08709 1/20 0.42
LTA4H P09960 1/20 0.42
F3 P13726 1/20 0.42
NR4A2 P43354 1/20 0.42
PARP1 P09874 1/20 0.42
ROCK2 O75116 1/20 0.39
CMA1 P23946 1/20 0.38
JAK3 P52333 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31227194 0.81 CHEK1 (0.51) CHEK1JAK2RPS6KA3MELKSTK24
SCHEMBL25151113 0.81 CHEK1 (0.47) CHEK1JAK2RPS6KA3MELKSTK24
SCHEMBL28870331 0.81 CHEK1 (0.51) CHEK1JAK2RPS6KA3MELKSTK24
SCHEMBL20666339 0.78 CHEK1 (0.44) CHEK1JAK2RPS6KA3MELKSTK24
SCHEMBL30032474 0.72 ADRB1 (0.49) CHEK1
SCHEMBL1050400 0.72 CHEK1 (0.49) CHEK1JAK2RPS6KA3MELKSTK24
SCHEMBL30381452 0.72 CHEK1 (0.49) CHEK1JAK2RPS6KA3MELKSTK24
SCHEMBL838245 0.71 AHR (0.54) CHEK1AHRF7LTA4HF3
SCHEMBL1536304 0.71 CHEK1 (0.61) CHEK1AHRF7LTA4HF3
SCHEMBL6804986 0.71 CHEK1 (0.56) CHEK1JAK2RPS6KA3MELKSTK24

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250026774-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2025-01-23 US disclosed
CN-119176843-A Organic electroluminescent material and device 环球展览公司 2024-12-24 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250026774-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES NR1H2, NR1H3, RO60 CHEK1 3932/4885JAK2 3015/4885RPS6KA3 1915/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.