Cytarabine

Cytarabine

SCHEMBL3140

Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

POLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PRIM1PRIM2

The experimentally established mechanism targets of Cytarabine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 1.00
MTOR P42345 2/20 1.00
THRB P10828 1/20 1.00
MDM2 Q00987 1/20 1.00
NCOA1 Q15788 1/20 1.00
NCOA3 Q9Y6Q9 1/20 1.00
ALDH1A1 P00352 2/20 0.64
GMNN O75496 1/20 0.64
TP53 P04637 1/20 0.64
NFKB1 P19838 1/20 0.64
DNMT1 P26358 1/20 0.64
THPO P40225 1/20 0.64
HTT P42858 1/20 0.64
RAB9A P51151 1/20 0.64
BLM P54132 1/20 0.64
HBB P68871 1/20 0.64
PMP22 Q01453 1/20 0.64
MAPT P10636 1/20 0.61
CDA P32320 1/20 0.61
SMN1; SMN2 Q16637 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cytarabine SCHEMBL787927 1.00 LMNA (1.00) LMNAMTORTHRBMDM2NCOA1
Cytarabine SCHEMBL471171 1.00 LMNA (1.00) LMNAMTORTHRBMDM2NCOA1
Cytarabine SCHEMBL12202579 1.00 LMNA (1.00) LMNAMTORTHRBMDM2NCOA1
Cytarabine SCHEMBL329878 1.00 LMNA (1.00) LMNAMTORTHRBMDM2NCOA1
Cytarabine SCHEMBL172274 1.00 LMNA (1.00) LMNAMTORTHRBMDM2NCOA1
Cytarabine SCHEMBL14644972 1.00 LMNA (1.00) LMNAMTORTHRBMDM2NCOA1
Cytarabine SCHEMBL23066241 1.00 LMNA (1.00) LMNAMTORTHRBMDM2NCOA1
Cytarabine SCHEMBL17993618 1.00 LMNA (1.00) LMNAMTORTHRBMDM2NCOA1
Cytarabine SCHEMBL14853684 1.00 LMNA (1.00) LMNAMTORTHRBMDM2NCOA1
Cytarabine SCHEMBL20546595 1.00 LMNA (1.00) LMNAMTORTHRBMDM2NCOA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 220816 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2026-05-28 US claimed
EP-4746876-A1 UDP-GLUCOSE CERAMIDE GLUCOSYLTRANSFERASE SYNTHASE (UGCG) INHIBITORS IN THE TREATMENT OF CANCER Katholieke Universiteit Leuven (BE) 2026-05-27 EP claimed
EP-3607938-B1 PHARMACEUTICAL COMPOSITION SOVIC BRKICIC LJILJANA (HR) 2026-05-27 EP claimed
EP-4747263-A1 LIPID NANOPARTICLES AND USES THEREOF University of Connecticut (US) 2026-05-27 EP claimed
EP-4748859-A2 CHEMICALLY AND PHOTOCHEMICALLY INITIATED CELL MEMBRANE BLEBBING TO INDUCE CELL VESICLE PRODUCTION, MODIFICATIONS THEREOF, AND USES THEREOF The Regents of the University of California (US) 2026-05-27 EP claimed
CN-116209439-B Cereblon protein modulators Saint Jude Children's Research Hospital Ltd. (US) 2026-05-26 CN claimed
US-20260137686-A1 SOLID PHARMACEUTICAL FORMULATION OF PARP INHIBITORS AND USE THEREOF IMPACT THERAPEUTICS SHANGHAI INC (CN) 2026-05-21 US claimed
US-20260137700-A1 PHARMACEUTICAL COMBINATION OF PRMT5 INHIBITOR AND DNA DAMAGE-INDUCING SUBSTANCE SK BIOPHARMACEUTICALS CO LTD (KR) 2026-05-21 US claimed
US-20260137674-A1 COMBINATION THERAPY USING A KRAS G12D INHIBITOR, AND A NUCLEOSIDE ANALOG, AND/OR A MICROTUBULE INHIBITOR INCYTE CORP (US) 2026-05-21 US claimed
WO-2026105121-A1 ANTICANCER FORMULATIONS AND USES THEREOF INTRAGEL THERAPEUTICS LTD. (IL) 2026-05-21 WO claimed
US-4283394-A ANTICARCINOGENIC AGENTS RESEARCH CORPORATION (US) 1981-08-11 US claimed
WO-1981002164-A1 SEVEN-MEMBERED RING COMPOUNDS AS INHIBITORS OF CYTIDINE DEAMINASE US COMMERCE (US) 1981-08-06 WO claimed
US-4275057-A CANCER AND ANTITUMOR DRUG RESEARCH THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH, EDUCATION AND WELFARE (US) 1981-06-23 US claimed
WO-1981001145-A1 HYDROLYTIC ENZYME-ACTIVATIBLE PRO-DRUGS UNIV ILLINOIS (US) 1981-04-30 WO claimed
WO-1981000410-A1 CYTOTOXIC NUCLEOSIDE-CORTICOSTEROID PHOSPHODIESTERS RESEARCH CORP (US) 1981-02-19 WO claimed
EP-0010964-A1 Ravidomycin, process of preparation and pharmaceutical compositions containing same AYERST, MCKENNA AND HARRISON INC. (CA) 1980-05-14 EP claimed
US-4145414-A ANTIVIRAL, IMMUNOSUPPRESSIVE, ANTILEUKEMIA THE UPJOHN COMPANY (US) 1979-03-20 US claimed
US-4093607-A ANTITUMOR ANTIBODY, ANTICANCER DRUG YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) 1978-06-06 US claimed
US-4017606-A CYTOSINE ARABINOSIDE AND HYDROGENATED PYRIMIDINE NUCLEOSIDES THE UPJOHN COMPANY (US) 1977-04-12 US claimed
US-3950325-A Novel process for preparing 2,2'-cyclocytidine or 1-β-D-arabinofuranosyl cytosine TANABE SEIYAKU CO., LTD. (JA) 1976-04-13 US claimed