CHI3L1

Chitinase-3-like protein 1 · P36222 · CHI3L1 on Sugi Atlas →

2,517 patent compounds predicted against CHI3L1, 1,466 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Hydrochloric Acid (SCHEMBL25381823)	0.81	16/20
Hydrochloric Acid (SCHEMBL25383460)	0.76	16/20
Trifluoroacetic Acid (SCHEMBL25382714)	0.83	15/20
SCHEMBL25383307	0.77	15/20
Hydrochloric Acid (SCHEMBL25382935)	0.73	15/20
Trifluoroacetic Acid (SCHEMBL25383319)	0.71	15/20
Trifluoroacetic Acid (SCHEMBL25383012)	0.66	15/20
Hydrochloric Acid (SCHEMBL25382774)	0.60	15/20
Hydrochloric Acid (SCHEMBL25382780)	0.60	15/20
Hydrochloric Acid (SCHEMBL25383458)	0.52	15/20
Trifluoroacetic Acid (SCHEMBL25383380)	0.85	14/20
Trifluoroacetic Acid (SCHEMBL25383433)	0.75	14/20
Hydrochloric Acid (SCHEMBL25382443)	0.74	14/20
SCHEMBL25383426	0.73	14/20
Trifluoroacetic Acid (SCHEMBL25382546)	0.71	14/20
Hydrochloric Acid (SCHEMBL25382807)	0.70	14/20
Hydrochloric Acid (SCHEMBL25382812)	0.62	14/20
SCHEMBL25382884	0.62	14/20
Hydrochloric Acid (SCHEMBL25382527)	0.61	14/20
Trifluoroacetic Acid (SCHEMBL25381927)	0.60	14/20

Clinical trials — most relevant to CHI3L1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Allogeneic Adipose Tissue-derived Mesenchymal Stem Cells in Ischemic Stroke	PHASE2	UNKNOWN
Effects of Anti-TSLP in Patients With Asthma	PHASE2	COMPLETED
Exploration Of Key Targets And Biomarkers Involved In An Allergic Response In Subjects With Allergic Rhinitis (Hay Fever)	PHASE1	COMPLETED
GSNOR Phenotyping/GSNO Challenge in Severe Asthma	EARLY_PHASE1	COMPLETED
The Relationship Between Single Nucleotide Polymorphisms of Chitinase 3-like 1 Gene,YKL-40 Serum Levels and Adult Asthma	nan	UNKNOWN
The Role of Peripheral and Tissue Chitinase 3-like 1 Protein Levels as a Bio-marker in IBD	nan	COMPLETED
Chitinases and Transforming Growth Factor Beta (TGFB) in Human Asthma	nan	COMPLETED
Tear Proteins, Conjunctival Cells and Imaging Eyes in Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients	nan	COMPLETED
The Genetics of Chiari Type I Malformation	nan	COMPLETED
National Psoriasis Foundation - Dendritic Cell-Specific Transmembrane Protein (DC-Stamp) Biomarker Study	nan	COMPLETED
The Role of Quantitative CT and Radiomic Biomarkers for Precision Medicine in Pulmonary Fibrosis	nan	RECRUITING
Transcriptional and Immune Parameters of Response to Belimumab	nan	COMPLETED
Comparison of Uncomplicated Candidemia Therapy Duration in Children	nan	RECRUITING
Transforming Research and Clinical Knowledge in Traumatic Brain Injury	nan	COMPLETED
Salivary Biomarkers in Pediatric Traumatic Brain Injury	nan	COMPLETED
Evaluation of TNF-α, IL-17A, and YKL-40 in GCF and Serum of Psoriasis Patients and Healthy Controls	nan	ACTIVE_NOT_RECRUITING
Belimumab in SLE Synovial Inflammation and Lymph Nodes	nan	UNKNOWN
Biomarker Levels as A Predictor of Concussion Severity OUTcomes (BlacOut)	nan	COMPLETED
Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors	nan	COMPLETED
Multi-Vendor Multi-Site Novel Accelerated MRI Relaxometry	nan	RECRUITING
Deep Phenotyping of Cutaneous Lupus Erythematosus	nan	UNKNOWN
Neurocognitive Impairment in Pediatric Patients With Meningoencephalitis and Sepsis-associated Encephalopathy	nan	COMPLETED
Searching for Diagnostic/Prognostic Biomarkers in SLE With Renal Involvement by Proteomic Techniques	nan	COMPLETED
Peripheral Arterial Disease Biomarkers	nan	NOT_YET_RECRUITING
Biomarker for Mannosidosis Disease (BioMannosidosis)	nan	WITHDRAWN
Eosinophil β1 Integrin Activation as a Biomarker for Eosinophilic Esophagitis	nan	COMPLETED
Blood-based Biomarkers for the Prognosis of Sports Related Concussion	nan	COMPLETED
Endocan Predictive Value in Postcardiac Surgery Acute Respiratory Failure.	nan	UNKNOWN
Significance of Biological Markers in Patients With Acute Lung Injury/Acute Respiratory Disease	nan	COMPLETED
Biological Markers in Patients With Pancreatic Cancer Experiencing Weight Loss	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CHI3L1 binder may also engage these)

Protein	Name	Similarity
Q7YS85	—	1.000	Q7YS85 →
P30922	—	1.000	P30922 →
Q9WTV1	—	0.999	Q9WTV1 →
Q29411	—	0.998	Q29411 →
Q61362	—	0.998	Q61362 →
Q5RBP6	—	0.996	Q5RBP6 →
Q8SPQ0	—	0.994	Q8SPQ0 →
CHI3L2	Chitinase-3-like protein 2	0.993	landscape →
O35744	—	0.992	O35744 →
Q6TMG6	—	0.991	Q6TMG6 →
Q91Z98	—	0.988	Q91Z98 →
CHIT1	Chitotriosidase-1	0.986	landscape →
Q9D7Q1	—	0.985	Q9D7Q1 →
Q6RY07	—	0.978	Q6RY07 →
Q95M17	—	0.973	Q95M17 →
Q2PQM7	—	0.973	Q2PQM7 →
Q8T0R7	—	0.973	Q8T0R7 →
Q91XA9	—	0.972	Q91XA9 →
Q9V3D4	—	0.971	Q9V3D4 →
Q9GV28	—	0.971	Q9GV28 →
P31428	—	0.970	P31428 →
P29030	—	0.970	P29030 →
Q11174	—	0.969	Q11174 →
Q9C525	—	0.969	Q9C525 →
Q8MX32	—	0.969	Q8MX32 →
Q9W092	—	0.969	Q9W092 →
Q8MX31	—	0.969	Q8MX31 →
Q8MLZ7	—	0.968	Q8MLZ7 →
Q8WXQ8	—	0.968	Q8WXQ8 →
A3C053	—	0.968	A3C053 →