Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA4 | P22748 | 2/20 | 0.41 |
| ▸ | CA6 | P23280 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8725872 | 1.00 | TSHR (0.59) | TSHRMAPTALDH1A1ARSRD5A2 | |
| SCHEMBL7759639 | 0.84 | TSHR (0.63) | TSHRMAPTALDH1A1SRD5A2SMN1; SMN2 | |
| SCHEMBL27554872 | 0.81 | TSHR (0.59) | TSHRMAPTALDH1A1SRD5A2SMN1; SMN2 | |
| SCHEMBL4476255 | 0.78 | CA12 (0.57) | TSHRMAPTALDH1A1ARSMN1; SMN2 | |
| SCHEMBL701970 | 0.78 | TAS1R3 (0.50) | TSHRMAPTALDH1A1ARSMN1; SMN2 | |
| SCHEMBL10453980 | 0.78 | AR (0.49) | TSHRMAPTALDH1A1ARSMN1; SMN2 | |
| SCHEMBL28154028 | 0.77 | LMNA (0.49) | TSHRMAPTALDH1A1ARSMN1; SMN2 | |
| SCHEMBL7275002 | 0.77 | CDC25B (0.50) | TSHRMAPTALDH1A1ARSMN1; SMN2 | |
| SCHEMBL8352471 | 0.74 | TSHR (1.00) | TSHRMAPTALDH1A1SRD5A2KMT2A | |
| SCHEMBL371998 | 0.74 | TSHR (1.00) | TSHRMAPTALDH1A1SRD5A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739682-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008058-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |