Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.45 |
| ▸ | LPL | P06858 | 4/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649267 | 1.00 | LIPG (0.45) | LIPGLPLTDO2AKR1C3AKR1C2 | |
| SCHEMBL2648752 | 0.85 | LPL (0.47) | LIPGLPLTDO2ROCK1PDGFRB | |
| SCHEMBL28470742 | 0.84 | LIPG (0.60) | LIPGLPLTDO2ROCK1PDGFRB | |
| SCHEMBL6218782 | 0.84 | LPL (0.48) | LIPGLPLTDO2ROCK1PDGFRB | |
| SCHEMBL20615766 | 0.83 | LPL (0.43) | LIPGLPLTDO2ROCK1PDGFRB | |
| SCHEMBL2651616 | 0.82 | LPL (0.42) | LIPGLPLTDO2ROCK1PDGFRB | |
| SCHEMBL22636737 | 0.81 | LIPG (0.45) | LIPGLPLTDO2PDGFRBKDR | |
| SCHEMBL29430844 | 0.81 | LIPG (0.45) | LIPGLPLTDO2PDGFRBKDR | |
| SCHEMBL20905062 | 0.81 | LIPG (0.50) | LIPGLPLTDO2ROCK1PDGFRB | |
| SCHEMBL31642814 | 0.80 | LIPG (0.48) | LIPGLPLPDGFRBKDRCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739682-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008058-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |