Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 3/20 | 0.59 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.52 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 3/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | GRN | P28799 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17755106 | 0.86 | TPMT (0.61) | TPMTHCAR1HCAR2TTRRXRA | |
| SCHEMBL28283450 | 0.86 | TPMT (0.46) | TPMTHCAR1TTRRXRARXRB | |
| SCHEMBL22081877 | 0.83 | TPMT (0.57) | TPMTHCAR1HCAR2TTRRXRA | |
| SCHEMBL16957565 | 0.83 | TPMT (0.57) | TPMTHCAR1HCAR2TTRRXRA | |
| SCHEMBL22081904 | 0.80 | ALDH1A1 (0.46) | TSHRALOX15ADRB1ADRB3ADRB2 | |
| SCHEMBL16094124 | 0.79 | TSHR (0.44) | TPMTTSHRGRNSORT1ADRB2 | |
| SCHEMBL9027044 | 0.79 | TSHR (0.44) | TPMTTSHRGRNSORT1ADRB2 | |
| SCHEMBL11898232 | 0.79 | TSHR (0.44) | TPMTTSHRGRNSORT1ADRB2 | |
| SCHEMBL19667846 | 0.79 | GABRA1 (0.42) | TSHRGRNSORT1ADRB2 | |
| SCHEMBL22926414 | 0.78 | TPMT (0.61) | TPMTHCAR1HCAR2TTRRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739682-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008058-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |