Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 5/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 9/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL439379 | 0.84 | ALDH1A1 (0.41) | ALDH1A1ALOX15TSHRNAMPTGAA | |
| SCHEMBL5337565 | 0.77 | GRM1 (0.58) | JAK1NAMPT | |
| SCHEMBL31401167 | 0.76 | MEN1 (0.45) | JAK1ALDH1A1ALOX15TSHRNAMPT | |
| SCHEMBL171408 | 0.75 | GRM5 (0.50) | ALDH1A1ALOX15GAASMN1; SMN2MAPT | |
| SCHEMBL31401537 | 0.73 | JAK1 (0.41) | JAK1JAK2TYK2ALDH1A1ALOX15 | |
| SCHEMBL5348848 | 0.73 | QDPR (0.45) | ALOX15KDM4E | |
| SCHEMBL10255367 | 0.69 | ALDH1A1 (0.45) | JAK1JAK2TYK2ALDH1A1ALOX15 | |
| SCHEMBL20597915 | 0.69 | ALDH1A1 (0.46) | JAK1JAK2TYK2ALDH1A1ALOX15 | |
| SCHEMBL14761667 | 0.69 | ALDH1A1 (0.42) | ALDH1A1ALOX15TSHRGAAKDM4E | |
| SCHEMBL29668566 | 0.69 | ALDH1A1 (0.41) | ALDH1A1ALOX15TSHRNAMPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739682-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008058-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |