Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TPMT | P51580 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | C1S | P09871 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12128205 | 1.00 | PARP1 (0.46) | PARP1SMN1; SMN2TPMTVNN1MAP4K4 | |
| SCHEMBL12128201 | 0.83 | PRSS1 (0.36) | PARP1SMN1; SMN2TPMTVNN1PRSS1 | |
| SCHEMBL30525077 | 0.82 | TPMT (0.61) | SMN1; SMN2TPMTCA2ALDH1A1CA12 | |
| SCHEMBL16999094 | 0.82 | FFAR4 (0.44) | SMN1; SMN2TPMTALDH1A1 | |
| SCHEMBL20790528 | 0.82 | TPMT (0.61) | SMN1; SMN2TPMTCA2ALDH1A1CA12 | |
| SCHEMBL1172413 | 0.81 | MAP4K4 (0.41) | PARP1VNN1MAP4K4CA2PARP10 | |
| SCHEMBL25159936 | 0.79 | PARP1 (0.44) | PARP1SMN1; SMN2VNN1MAP4K4CA2 | |
| SCHEMBL23224098 | 0.79 | ADRA1D (0.46) | PARP1TPMTVNN1MAP4K4CA2 | |
| SCHEMBL501850 | 0.79 | PARP1 (0.60) | PARP1SMN1; SMN2TPMTPRSS1PRSS2 | |
| SCHEMBL12865158 | 0.79 | PARP1 (0.60) | PARP1SMN1; SMN2TPMTCA2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739682-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008058-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |