SCHEMBL31406970

SCHEMBL31406970

COc1ccc(C(OC[C@]2(CO)O[C@@H](c3csc4c(NC(=O)OC(C)(C)C)ncnc34)[C@@H]3OC(C)(C)O[C@@H]32)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ NPSR1 Q6W5P4 1/20 0.30
▸ GPR119 Q8TDV5 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29788184 1.00 NPSR1 (0.30) NPSR1GPR119
SCHEMBL29788385 0.93 — —
SCHEMBL17453464 0.93 ADORA3 (0.31) —
SCHEMBL17453467 0.86 — —
SCHEMBL31406969 0.85 GPR119 (0.33) NPSR1GPR119
SCHEMBL17465415 0.85 GPR119 (0.33) NPSR1GPR119
SCHEMBL19644594 0.84 GPR119 (0.32) GPR119
SCHEMBL17465422 0.83 GPR119 (0.32) NPSR1GPR119
SCHEMBL17465421 0.83 GPR119 (0.32) NPSR1GPR119
SCHEMBL30104255 0.82 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250042913-A1 THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS GILEAD SCIENCES INC (US) 2025-02-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250042913-A1 THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS DPYD, TYMS, TYMP NPSR1 2592/4885GPR119 3447/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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