SCHEMBL31413392

SCHEMBL31413392

CC(C)(C)OC(=O)N1CC[C@H](Oc2cc3c(cc2F)C(=O)N(C2CCC(=O)NC2=O)C3)C1

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 17/20 0.46
▸ IKZF2 Q9UKS7 2/20 0.43
▸ IKZF1 Q13422 1/20 0.43
▸ DDB1 Q16531 5/20 0.42
▸ CSNK1A1 P48729 2/20 0.40
▸ GPR119 Q8TDV5 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30718659 1.00 CRBN (0.46) CRBNIKZF2IKZF1DDB1CSNK1A1
SCHEMBL27146424 0.88 CRBN (0.48) CRBNIKZF2IKZF1CSNK1A1
SCHEMBL24819319 0.88 IKZF2 (0.44) CRBNIKZF2IKZF1DDB1CSNK1A1
SCHEMBL31413474 0.85 CRBN (0.52) CRBNIKZF2DDB1CSNK1A1
SCHEMBL32669075 0.85 CRBN (0.52) CRBNIKZF2DDB1CSNK1A1
SCHEMBL22345848 0.83 IKZF2 (0.59) CRBNIKZF2IKZF1DDB1CSNK1A1
SCHEMBL20231914 0.82 CRBN (0.53) CRBNIKZF2IKZF1DDB1CSNK1A1
SCHEMBL29546738 0.82 CRBN (0.53) CRBNIKZF2IKZF1DDB1CSNK1A1
SCHEMBL31736558 0.80 CRBN (0.48) CRBNIKZF2IKZF1DDB1CSNK1A1
SCHEMBL20046226 0.80 CRBN (0.54) CRBNIKZF2DDB1CSNK1A1GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119325469-A WEE1 degrading compounds and uses thereof 百时美施贵宝公司 2025-01-17 — — CN disclosed
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