Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Tetrabuthylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.44 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.67 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CDC25A | P30304 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrabuthylammonium SCHEMBL703752 | 1.00 | SLC22A1 (0.67) | SLC22A1SLC22A2ALDH1A1TP53CYP3A4 | |
| Tetrabuthylammonium SCHEMBL9439997 | 0.97 | SLC22A1 (0.63) | SLC22A1SLC22A2ALDH1A1TP53CYP3A4 | |
| Tetrabuthylammonium SCHEMBL19834900 | 0.97 | SLC22A1 (0.71) | SLC22A1SLC22A2ALDH1A1TP53CYP3A4 | |
| Tetrabuthylammonium SCHEMBL49814 | 0.97 | SLC22A1 (0.71) | SLC22A1SLC22A2ALDH1A1TP53CYP3A4 | |
| Tetrabuthylammonium SCHEMBL7638948 | 0.95 | SLC22A1 (0.60) | SLC22A1SLC22A2ALDH1A1TP53CYP3A4 | |
| Tetrabuthylammonium SCHEMBL29164920 | 0.94 | SLC22A1 (0.67) | SLC22A1SLC22A2ALDH1A1TP53CYP3A4 | |
| Tetrabuthylammonium SCHEMBL28973535 | 0.94 | SLC22A1 (0.67) | SLC22A1SLC22A2ALDH1A1TP53CYP3A4 | |
| Tetrabuthylammonium SCHEMBL28547695 | 0.94 | SLC22A1 (0.67) | SLC22A1SLC22A2ALDH1A1TP53CYP3A4 | |
| Tetrabuthylammonium SCHEMBL31067882 | 0.94 | SLC22A1 (0.67) | SLC22A1SLC22A2ALDH1A1TP53CYP3A4 | |
| Tetrabuthylammonium SCHEMBL3795562 | 0.94 | SLC22A1 (0.67) | SLC22A1SLC22A2ALDH1A1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100001228-A1 | Latent heat storage substance, clathrate hyrate or slurry thereof, method for producing clathrate hyrate or slurry thereof, and latent heat storage agent | JFE ENGINEERING CORPORATION | 2010-01-07 | — | — | US | disclosed |
| EP-2123730-A1 | LATENT HEAT STORAGE SUBSTANCE, INCLUSION HYDRATE OR SLURRY THEREOF, METHOD FOR PRODUCING INCLUSION HYDRATE OR SLURRY THEREOF, AND LATENT HEAT STORAGE AGENT | JFE Engineering Corporation (JP) | 2009-11-25 | — | — | EP | disclosed |
| US-20020103328-A1 | Aromatic polycarbonate composition, production process therefor and molded product thereof | TEIJIN LIMITED | 2002-08-01 | — | — | US | disclosed |
| US-5939290-A | Modified sialyl Lewisx compounds | ALBERTA RESEARCH COUNCIL (CA) | 1999-08-17 | — | — | US | disclosed |
| US-5882901-A | SIALYLATING SPECIFIED OLIGOSACCHARIDE WITH SIALYLTRANSFERASE, FUCOSYLATING WITH FUCOSYLTRANSFERASE | ALBERTA RESEARCH COUNCIL (CA) | 1999-03-16 | — | — | US | disclosed |
| US-5872096-A | MODULATION OF A CELL MEDIATED IMMUNE RESPONSE, USED TO PREPARE ARTIFICIAL ANTIGENS FOR THE GENERATION OF MONOCLONAL OR POLYCLONAL ANTIBODIES | ALBERTA RESEARCH COUNCIL (CA) | 1999-02-16 | — | — | US | disclosed |
| US-5759993-A | OLIGOSACCHARIDES AS IMMUNOMODULATORS | ALBERTA RESEARCH COUNCIL (CA) | 1998-06-02 | — | — | US | disclosed |
| US-5646123-A | Time dependent administration of oligosaccharide glycosides related to blood group determinants having a type I or type II core structure in reducing inflammation in a sensitized mammal arising form exposure to an antigen | ALBERTA RESEARCH COUNCIL (CA) | 1997-07-08 | — | — | US | disclosed |
| US-5580858-A | Immunosuppressive and tolerogenic modified Lewisx compounds | ALBERTA RESEARCH COUNCIL (CA) | 1996-12-03 | — | — | US | disclosed |
| US-5550155-A | ANTIINFLAMMATORY AGENTS | ALBERTA RESEARCH COUNCIL (CA) | 1996-08-27 | — | — | US | disclosed |
| EP-0591256-A1 | METHODS FOR THE SYNTHESIS OF MONOFUCOSYLATED OLIGOSACCHARIDES TERMINATING IN DI-N-ACETYLLACTOSAMINYL STRUCTURES | GLYCOMED INCORPORATED (US) | 1994-04-13 | — | — | EP | disclosed |
| EP-0589951-A1 | MODIFIED SIALYL LEWIS?X COMPOUNDS | GLYCOMED INCORPORATED (US) | 1994-04-06 | — | — | EP | disclosed |
| EP-0588852-A1 | IMMUNOSUPPRESSIVE AND TOLEROGENIC OLIGOSACCHARIDE DERIVATIVES | GLYCOMED INCORPORATED (US) | 1994-03-30 | — | — | EP | disclosed |
| EP-0588848-A1 | MODIFIED SIALYL LEWIS?A COMPOUNDS | GLYCOMED INCORPORATED (US) | 1994-03-30 | — | — | EP | disclosed |
| WO-1993024505-A1 | REDUCING INFLAMMATION BY TIME DEPENDENT ADMINISTRATION OF OLIGOSACCHARIDES GLYCOSIDES RELATED TO BLOOD GROUP DETERMINANTS | ALBERTA RESEARCH COUNCIL (CA) | 1993-12-09 | — | — | WO | disclosed |
| WO-1992022662-A1 | METHODS FOR THE SYNTHESIS OF MONOFUCOSYLATED OLIGOSACCHARIDES TERMINATING IN DI-N-ACETYLLACTOSAMINYL STRUCTURES | ALBERTA RESEARCH COUNCIL (CA) | 1992-12-23 | — | — | WO | disclosed |
| WO-1992022565-A1 | MODIFIED SIALYL LEWISX COMPOUNDS | ALBERTA RESEARCH COUNCIL (CA) | 1992-12-23 | — | — | WO | disclosed |
| WO-1992022564-A1 | IMMUNOSUPPRESSIVE AND TOLEROGENIC MODIFIED LEWISX AND LEWISA COMPOUNDS | ALBERTA RESEARCH COUNCIL (CA) | 1992-12-23 | — | — | WO | disclosed |
| WO-1992022301-A1 | IMMUNOSUPPRESSIVE AND TOLEROGENIC OLIGOSACCHARIDE DERIVATIVES | ALBERTA RESEARCH COUNCIL (CA) | 1992-12-23 | — | — | WO | disclosed |
| WO-1992022563-A1 | MODIFIED SIALYL LEWISA COMPOUNDS | ALBERTA RESEARCH COUNCIL (CA) | 1992-12-23 | — | — | WO | disclosed |