Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL314190 | 0.76 | HRH4 (0.43) | HRH4MAPTALDH1A1RAB9AKMT2A | |
| SCHEMBL314100 | 0.71 | LMNA (0.44) | HRH4MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL10901794 | 0.64 | NPC1 (0.46) | MAPTRAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL3928656 | 0.63 | MEN1 (0.39) | MAPTALDH1A1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL313994 | 0.62 | MKNK1 (0.33) | ALDH1A1RAB9AKMT2ANPC1HPGD | |
| Hydrochloric Acid SCHEMBL735112 | 0.62 | MEN1 (0.39) | MAPTALDH1A1KMT2AHPGDSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL313993 | 0.62 | BACE1 (0.39) | MAPTALDH1A1RAB9AKMT2ANPC1 | |
| SCHEMBL313493 | 0.61 | BCHE (0.43) | MAPTALDH1A1RAB9ANPC1HPGD | |
| SCHEMBL10900184 | 0.59 | RAB9A (0.46) | HRH4MAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL10901831 | 0.58 | MAPT (0.53) | HRH4MAPTALDH1A1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093388-B2 | 3-aza spiro[5,5]undec-8-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors | NEUROSEARCH A/S (DK) | 2012-01-10 | — | — | US | disclosed |