SCHEMBL31420224

SCHEMBL31420224

Cc1n[nH]c(C)c1-c1ccc2nc(NC(=O)[C@H]3CCN(C(=O)OC(C)(C)C)C3)sc2c1

nearest known ligand 0.52

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.52
▸ ABL1 P00519 7/20 0.49
▸ MAP4K1 Q92918 8/20 0.48
▸ PTPN2 P17706 1/20 0.46
▸ PTPN1 P18031 1/20 0.46
▸ PTPN6 P29350 1/20 0.46
▸ CLK1 P49759 1/20 0.46
▸ KIT P10721 1/20 0.45
▸ PDGFRA P16234 1/20 0.45
▸ LMNA P02545 1/20 0.45
▸ MAPK1 P28482 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31420255 0.94 ABL1 (0.48) L3MBTL1ABL1MAP4K1PTPN2PTPN1
SCHEMBL31420310 0.94 ABL1 (0.48) L3MBTL1ABL1MAP4K1PTPN2PTPN1
SCHEMBL30247993 0.86 L3MBTL1 (0.55) L3MBTL1ABL1PTPN2PTPN1PTPN6
SCHEMBL30248411 0.84 ABL1 (0.56) L3MBTL1ABL1MAP4K1PTPN2PTPN1
SCHEMBL31420252 0.83 L3MBTL1 (0.51) L3MBTL1ABL1PTPN2PTPN1PTPN6
SCHEMBL30248235 0.82 L3MBTL1 (0.57) L3MBTL1PTPN2PTPN1PTPN6CLK1
SCHEMBL27311609 0.82 L3MBTL1 (0.57) L3MBTL1PTPN2PTPN1PTPN6CLK1
SCHEMBL30248371 0.82 L3MBTL1 (0.57) L3MBTL1PTPN2PTPN1PTPN6CLK1
SCHEMBL31420249 0.82 NPC1 (0.52) L3MBTL1ABL1PTPN2PTPN1PTPN6
SCHEMBL17632727 0.82 MAP4K1 (0.52) ABL1MAP4K1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119528901-B Thiazole compound, dessumo and/or deubiquitinase inhibitor, and preparation methods and applications thereof Shanghai tongji hospital (CN) 2026-05-26 — — CN disclosed
CN-119528901-A Thiazole compound, dessumo and/or deubiquitinase inhibitor, and preparation methods and applications thereof 上海市同济医院 2025-02-28 — — CN disclosed
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