SCHEMBL31424741

SCHEMBL31424741

Cc1nc2c(Oc3ccccc3F)cc(CO)cc2[nH]c1=O

nearest known ligand 0.40

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 12/20 0.40
PARP1 P09874 3/20 0.39
LMNA P02545 1/20 0.35
HTT P42858 1/20 0.35
BRAF P15056 1/20 0.35
DAO P14920 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31424629 0.89 BRD4 (0.40) BRD4PARP1LMNAHTTDAO
SCHEMBL31424768 0.85 BRD4 (0.44) BRD4PARP1BRAF
SCHEMBL31424869 0.85 RHEB (0.42) BRD4
SCHEMBL31424579 0.83 BRD4 (0.40) BRD4BRAF
SCHEMBL31424754 0.81 DHODH (0.42) PARP1
SCHEMBL31424732 0.80 PARP1 (0.36) BRD4PARP1BRAF
SCHEMBL30979325 0.79 PARP1 (0.50) BRD4PARP1DAO
SCHEMBL31424857 0.78 RHEB (0.38) PARP1
SCHEMBL31424760 0.78 PARP1 (0.36) BRD4PARP1HTT
SCHEMBL31424567 0.77 HSD17B10 (0.38) PARP1LMNAHTTDAO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119431314-A Substituted nitrogen-containing bicyclic compounds and uses thereof 广东东阳光药业股份有限公司 2025-02-14 CN disclosed