SCHEMBL31426263

SCHEMBL31426263

Ic1cc2cnccc2o1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIM1 P11309 2/20 0.35
HASPIN Q8TF76 2/20 0.35
CYP2A6 P11509 3/20 0.34
PGR P06401 1/20 0.34
CYP19A1 P11511 1/20 0.33
PIM2 Q9P1W9 1/20 0.33
HDAC3 O15379 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC2 Q92769 1/20 0.33
NCOR2 Q9Y618 1/20 0.33
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
ALDH1A1 P00352 3/20 0.33
HSD17B10 Q99714 2/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
MKNK1 Q9BUB5 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
MAPT P10636 1/20 0.32
KDM4E B2RXH2 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18660624 1.00 PIM1 (0.35) PIM1HASPINCYP2A6PGRCYP19A1
SCHEMBL18660625 0.83 HASPIN (0.35) PIM1HASPINCYP2A6PGRCYP19A1
SCHEMBL15971544 0.75 CYP2A6 (0.34) PIM1CYP2A6PGRCYP19A1PIM2
SCHEMBL9241840 0.75 PRKCZ (0.39) PIM1CYP2A6PIM2HDAC3HDAC1
SCHEMBL126266 0.75 MAPT (0.51) CYP2A6HDAC3HDAC1HDAC2NCOR2
SCHEMBL6066606 0.72 CYP2A6 (0.40) CYP2A6HDAC3HDAC1HDAC2NCOR2
SCHEMBL5955063 0.72 NPC1 (0.42) PIM1CYP2A6PIM2HDAC3HDAC1
SCHEMBL6066592 0.71 LOXL2 (0.56) CYP2A6CYP19A1HDAC3HDAC1HDAC2
SCHEMBL10090598 0.71 CYP19A1 (0.37) CYP2A6CYP19A1HDAC3HDAC1HDAC2
SCHEMBL12152172 0.71 HDAC3 (0.38) CYP2A6CYP19A1HDAC3HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025049994-A1 COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF ONCOPIA THERAPEUTICS, INC. D/B/A SK LIFE SCIENCE LABS (US) 2025-03-06 WO disclosed