Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 3/20 | 0.56 |
| ▸ | CA2 | P00918 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15580847 | 0.93 | LMNA (0.62) | LMNAKDM4EGAAHPGDALDH1A1 | |
| SCHEMBL31431706 | 0.90 | LMNA (0.65) | LMNAKDM4EALOX15TSHRACMSD | |
| SCHEMBL20729906 | 0.88 | LMNA (0.57) | LMNAKDM4ECA1CA2GAA | |
| SCHEMBL29216695 | 0.88 | LMNA (0.61) | LMNAKDM4EALOX15TSHRACMSD | |
| SCHEMBL28220099 | 0.86 | KDM4E (0.61) | LMNAKDM4EALOX15TSHRACMSD | |
| SCHEMBL12308127 | 0.85 | HPGD (0.55) | LMNAKDM4EGAAHPGDALDH1A1 | |
| SCHEMBL31432223 | 0.84 | HPGD (0.61) | LMNAKDM4EALOX15TSHRACMSD | |
| SCHEMBL18157897 | 0.83 | LMNA (0.68) | LMNAKDM4ETSHRHPGDNPC1 | |
| SCHEMBL24218406 | 0.81 | LMNA (0.56) | LMNAKDM4EALOX15TSHRACMSD | |
| SCHEMBL29278807 | 0.81 | CA1 (0.71) | LMNAKDM4EALOX15TSHRACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025049326-A1 | TRICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | BIOCRYST PHARMACEUTICALS, INC. (US) | 2025-03-06 | — | — | WO | disclosed |