Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | AGER | Q15109 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12955221 | 0.88 | KMT2A (0.62) | KDM4EALDH1A1ALOX15TSHRL3MBTL1 | |
| Quinolinic Acid SCHEMBL14687247 | 0.84 | KDM4E (0.81) | KDM4EALDH1A1ALOX15TSHRL3MBTL1 | |
| SCHEMBL162691 | 0.81 | TSHR (0.51) | KDM4EALDH1A1TSHRL3MBTL1KMT2A | |
| SCHEMBL9213267 | 0.81 | KDM4E (0.61) | KDM4EALDH1A1ALOX15TSHRL3MBTL1 | |
| SCHEMBL11538362 | 0.80 | PRKCI (0.55) | KDM4EALDH1A1TSHRL3MBTL1KMT2A | |
| SCHEMBL30887046 | 0.79 | KDM4E (0.67) | KDM4EALDH1A1ALOX15TSHRL3MBTL1 | |
| SCHEMBL16088176 | 0.79 | KMT2A (0.56) | KDM4EALDH1A1ALOX15TSHRL3MBTL1 | |
| SCHEMBL8154709 | 0.79 | KMT2A (0.80) | KDM4EALDH1A1ALOX15TSHRL3MBTL1 | |
| Quinolinic Acid SCHEMBL69230 | 0.78 | KDM4E (1.00) | KDM4EALDH1A1ALOX15TSHRL3MBTL1 | |
| Quinolinic Acid SCHEMBL343618 | 0.78 | KDM4E (1.00) | KDM4EALDH1A1ALOX15TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025049326-A1 | TRICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | BIOCRYST PHARMACEUTICALS, INC. (US) | 2025-03-06 | — | — | WO | disclosed |