Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | APLNR | P35414 | 1/20 | 0.49 |
| ▸ | RAMP3 | O60896 | 13/20 | 0.47 |
| ▸ | CALCR | P30988 | 13/20 | 0.47 |
| ▸ | NPY2R | P49146 | 4/20 | 0.44 |
| ▸ | NPY4R | P50391 | 4/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.44 |
| ▸ | NPY1R | P25929 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31433197 | 1.00 | MAPK8 (0.50) | MAPK8MAPK9MAPK10APLNRRAMP3 | |
| SCHEMBL31433180 | 0.98 | MAPK8 (0.50) | MAPK8MAPK9MAPK10APLNRRAMP3 | |
| SCHEMBL31433297 | 0.98 | MAPK8 (0.50) | MAPK8MAPK9MAPK10APLNRRAMP3 | |
| SCHEMBL31433272 | 0.98 | APLNR (0.50) | MAPK8MAPK9MAPK10APLNRRAMP3 | |
| SCHEMBL31433294 | 0.97 | MAPK8 (0.49) | MAPK8MAPK9MAPK10APLNRRAMP3 | |
| SCHEMBL31433233 | 0.97 | MAPK8 (0.46) | MAPK8MAPK9MAPK10APLNRRAMP3 | |
| SCHEMBL31433388 | 0.96 | APLNR (0.50) | MAPK8MAPK9MAPK10APLNRRAMP3 | |
| SCHEMBL31433470 | 0.96 | MAPK8 (0.51) | MAPK8MAPK9MAPK10APLNRRAMP3 | |
| SCHEMBL31433289 | 0.96 | MAPK8 (0.47) | MAPK8MAPK9MAPK10APLNRRAMP3 | |
| SCHEMBL31433220 | 0.95 | RAMP3 (0.52) | MAPK8MAPK9MAPK10APLNRRAMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250074942-A1 | COMPOSITIONS AND METHODS FOR COVALENT PEPTIDE-BASED MODULATORS OF HLA-E | CALICO LIFE SCIENCES LLC (US) | 2025-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250074942-A1 | COMPOSITIONS AND METHODS FOR COVALENT PEPTIDE-BASED MODULATORS OF HLA-E | MICA, CD74, HLA-DRB1 | MAPK8 4358/4885MAPK9 3139/4885MAPK10 4246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.