Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | CYP46A1 | Q9Y6A2 | 7/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.34 |
| ▸ | CDK9 | P50750 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | MARS1 | P56192 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3146187 | 0.90 | MAP4K4 (0.38) | CCNT1CDK9CDK2 | |
| SCHEMBL3142552 | 0.89 | ABL1 (0.41) | — | |
| SCHEMBL3152373 | 0.85 | EGLN1 (0.41) | — | |
| SCHEMBL3147051 | 0.82 | FFAR4 (0.38) | ADORA2B | |
| SCHEMBL3156236 | 0.79 | ALDH1A1 (0.33) | — | |
| SCHEMBL3143345 | 0.79 | CYP46A1 (0.35) | ADORA2BCYP46A1CCNT1CDK9CDK2 | |
| SCHEMBL3147365 | 0.76 | ABL1 (0.37) | — | |
| SCHEMBL3142559 | 0.76 | PIK3CD (0.34) | ADORA2BCCNT1CDK9CDK2 | |
| SCHEMBL4818188 | 0.75 | KCNQ3 (0.43) | — | |
| SCHEMBL3147012 | 0.72 | FFAR4 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-B9 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2010-02-17 | — | — | EP | disclosed |
| EP-1979321-B1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2009-07-29 | — | — | EP | disclosed |