SCHEMBL31433519

SCHEMBL31433519

O=C1CCC(c2n[nH]c3c(F)c(C4CCN(CC5CCNCC5)CC4)ccc23)C(=O)N1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ DDB1 Q16531 8/20 0.37
▸ CRBN Q96SW2 8/20 0.37
▸ IKZF2 Q9UKS7 5/20 0.37
▸ IKZF1 Q13422 2/20 0.36
▸ HTR1A P08908 1/20 0.33
▸ DRD2 P14416 1/20 0.33
▸ DRD1 P21728 1/20 0.33
▸ HTR2A P28223 1/20 0.33
▸ HTR2C P28335 1/20 0.33
▸ DRD3 P35462 1/20 0.33
▸ HTR6 P50406 1/20 0.33
▸ OPRM1 P35372 2/20 0.32
▸ OPRK1 P41145 2/20 0.32
▸ OPRL1 P41146 2/20 0.32
▸ RBP4 P02753 2/20 0.32
▸ CCR2 P41597 1/20 0.31
▸ CACNA2D1 P54289 1/20 0.31
▸ CACNA1B Q00975 1/20 0.31
▸ CACNB1 Q02641 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31433918 0.88 DDB1 (0.41) DDB1CRBN
SCHEMBL31433673 0.83 DDB1 (0.47) DDB1CRBN
SCHEMBL26924652 0.83 DDB1 (0.51) DDB1CRBNIKZF2IKZF1DRD2
Hydrochloric Acid SCHEMBL31465248 0.82 DDB1 (0.50) DDB1CRBNIKZF2IKZF1DRD2
SCHEMBL31433754 0.80 IKZF2 (0.41) DDB1CRBNIKZF2
SCHEMBL31433947 0.77 DDB1 (0.52) DDB1CRBNIKZF2IKZF1DRD2
SCHEMBL31323627 0.76 DDB1 (0.38) DDB1CRBNIKZF2IKZF1HTR1A
SCHEMBL29321878 0.76 DDB1 (0.46) DDB1CRBN
SCHEMBL31433601 0.76 DDB1 (0.52) DDB1CRBN
SCHEMBL31434008 0.76 DDB1 (0.49) DDB1CRBNIKZF2IKZF1RBP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025050016-A1 TRICYCLIC QUINOLONE BCL6 BIFUNCTIONAL DEGRADERS Treeline Biosciences, Inc. (US) 2025-03-06 — — WO disclosed
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