SCHEMBL31433576

SCHEMBL31433576

CCOC(=O)c1c(Cl)c2cc(Br)c(F)cc2[nH]c1=O

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.47
PKM P14618 1/20 0.47
CSF1R P07333 1/20 0.46
LMNA P02545 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
ALDH1A1 P00352 1/20 0.45
KDM4E B2RXH2 1/20 0.44
KDM5A P29375 1/20 0.42
KDM5B Q9UGL1 1/20 0.42
MAP3K5 Q99683 1/20 0.41
ALOX15 P16050 2/20 0.40
MEN1 O00255 1/20 0.40
POLB P06746 1/20 0.40
KMT2A Q03164 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
TDP1 Q9NUW8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31433701 0.87 KDM5A (0.54) MAPTPKMCSF1RLMNAL3MBTL1
SCHEMBL1057337 0.81 CSF1R (0.56) MAPTCSF1RALDH1A1KDM4EKDM5A
SCHEMBL19052185 0.81 CSF1R (0.56) MAPTCSF1RALDH1A1KDM4EKDM5A
SCHEMBL13295306 0.78 CSF1R (0.58) MAPTCSF1RALDH1A1KDM4EKDM5A
SCHEMBL13739817 0.78 CSF1R (0.52) MAPTCSF1RLMNAALDH1A1KDM4E
SCHEMBL31433970 0.75 ALDH1A1 (0.46) MAPTPKML3MBTL1ALDH1A1KDM4E
SCHEMBL1061379 0.75 KDM4E (0.64) MAPTCSF1RLMNAALDH1A1KDM4E
SCHEMBL31544208 0.74 ALDH1A1 (0.52) MAPTLMNAL3MBTL1ALDH1A1KDM4E
SCHEMBL5104175 0.74 CSF1R (0.47) MAPTCSF1RLMNAALDH1A1KDM4E
SCHEMBL4696686 0.73 CSF1R (0.61) MAPTCSF1RLMNAALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025050016-A1 TRICYCLIC QUINOLONE BCL6 BIFUNCTIONAL DEGRADERS Treeline Biosciences, Inc. (US) 2025-03-06 WO disclosed