Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31433535 | 1.00 | TNF (0.39) | TNFBTKGPR119ALOX5APFEN1 | |
| SCHEMBL31434030 | 1.00 | TNF (0.39) | TNFBTKGPR119ALOX5APFEN1 | |
| SCHEMBL30732152 | 0.91 | TNF (0.44) | TNFBTKGPR119HTR6JAK1 | |
| SCHEMBL26927004 | 0.91 | TNF (0.44) | TNFBTKGPR119HTR6JAK1 | |
| SCHEMBL30732291 | 0.90 | GPR119 (0.39) | BTKGPR119HTR6JAK1PDE10A | |
| SCHEMBL30732183 | 0.90 | GPR119 (0.39) | BTKGPR119HTR6JAK1PDE10A | |
| SCHEMBL30732135 | 0.90 | GPR119 (0.39) | BTKGPR119HTR6JAK1PDE10A | |
| SCHEMBL30732290 | 0.90 | GPR119 (0.39) | BTKGPR119HTR6JAK1PDE10A | |
| SCHEMBL31434091 | 0.90 | GPR119 (0.35) | BTKGPR119HTR6JAK1GRM5 | |
| SCHEMBL31433742 | 0.90 | GPR119 (0.35) | BTKGPR119HTR6JAK1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025049964-A1 | BCL6 BIFUNCTIONAL DEGRADERS | Treeline Biosciences, Inc. (US) | 2025-03-06 | — | — | WO | disclosed |
| WO-2025050016-A1 | TRICYCLIC QUINOLONE BCL6 BIFUNCTIONAL DEGRADERS | Treeline Biosciences, Inc. (US) | 2025-03-06 | — | — | WO | disclosed |