SCHEMBL31435237

SCHEMBL31435237

N#Cc1cc(F)ccc1-c1nc(CN2CCC(C(=O)Nc3cccc(C(F)(F)F)c3)CC2)no1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
UBE2M P61081 5/20 0.51
DCUN1D1 Q96GG9 5/20 0.51
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
ALDH1A1 P00352 1/20 0.46
KDM4E B2RXH2 3/20 0.45
USP2 O75604 2/20 0.44
LMNA P02545 2/20 0.44
TSHR P16473 2/20 0.44
HSD17B10 Q99714 2/20 0.44
HTT P42858 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
CCR3 P51677 1/20 0.44
CTNNB1 P35222 3/20 0.43
TCF7L2 Q9NQB0 3/20 0.43
POLB P06746 1/20 0.42
MAPT P10636 1/20 0.42
ALOX15 P16050 1/20 0.42
ACKR3 P25106 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31435259 0.89 UBE2M (0.59) UBE2MDCUN1D1MEN1KMT2AALDH1A1
SCHEMBL31435226 0.86 UBE2M (0.57) UBE2MDCUN1D1MEN1KMT2AALDH1A1
SCHEMBL31435220 0.80 UBE2M (0.60) UBE2MDCUN1D1MEN1KMT2AALDH1A1
SCHEMBL31435224 0.80 DCUN1D1 (0.53) UBE2MDCUN1D1MEN1KMT2AALDH1A1
SCHEMBL31435229 0.79 DCUN1D1 (0.52) UBE2MDCUN1D1MEN1KMT2AALDH1A1
SCHEMBL31435238 0.79 DCUN1D1 (0.56) UBE2MDCUN1D1MEN1KMT2AALDH1A1
SCHEMBL31435236 0.74 UBE2M (0.43) UBE2MDCUN1D1MEN1KMT2AALDH1A1
SCHEMBL31435221 0.74 UBE2M (0.50) UBE2MDCUN1D1MEN1KMT2AALDH1A1
SCHEMBL31435231 0.69 UBE2M (0.46) UBE2MDCUN1D1MEN1KMT2AALDH1A1
SCHEMBL31435222 0.69 UBE2M (0.46) UBE2MDCUN1D1MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025090928-A1 COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISEASES AQUINNAH PHARMACEUTICALS, INC. (US) 2025-05-01 WO claimed
WO-2025090928-A1 COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISEASES AQUINNAH PHARMACEUTICALS, INC. (US) 2025-05-01 WO disclosed