Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 8/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005538 | 0.96 | GAA (0.52) | FAAHGAAKDM4ELMNAPOLB | |
| SCHEMBL2004199 | 0.93 | FAAH (0.66) | FAAHKDM4EPOLBMAPTSMN1; SMN2 | |
| SCHEMBL27729580 | 0.84 | FAAH (0.52) | FAAHKDM4EPOLBMAPTSMN1; SMN2 | |
| SCHEMBL2006893 | 0.84 | FAAH (0.63) | FAAHKDM4EPOLBMAPTSMN1; SMN2 | |
| SCHEMBL2005985 | 0.82 | TRPV1 (0.44) | GAAKDM4ELMNAPOLBMAPT | |
| SCHEMBL2004940 | 0.81 | FAAH (0.71) | FAAHLMNAMAPTSMN1; SMN2CNR1 | |
| SCHEMBL27749354 | 0.81 | CNR1 (0.49) | FAAHPOLBMAPTTP53SMN1; SMN2 | |
| SCHEMBL25155035 | 0.79 | GAA (0.59) | FAAHGAAKDM4ELMNAPOLB | |
| SCHEMBL12569101 | 0.77 | CNR1 (0.59) | FAAHPOLBMAPTSMN1; SMN2CNR1 | |
| SCHEMBL2004435 | 0.77 | FAAH (0.56) | FAAHPOLBMAPTSMN1; SMN2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981504-B1 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | REMYND NV (BE) | 2010-07-21 | — | — | EP | claimed |
| EP-1981504-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV Remynd (BE) | 2008-10-22 | — | — | EP | claimed |
| WO-2007090617-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | NV REMYND (BE) | 2007-08-16 | — | — | WO | claimed |