Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 18/20 | 0.55 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | USP1 | O94782 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3147079 | 0.90 | CRHR1 (0.64) | CRHR1 | |
| SCHEMBL3138221 | 0.89 | CRHR1 (0.63) | CRHR1 | |
| SCHEMBL3148132 | 0.88 | CRHR1 (0.53) | CRHR1KDM5BUSP1 | |
| SCHEMBL3152845 | 0.80 | CRHR1 (0.66) | CRHR1 | |
| SCHEMBL3151533 | 0.80 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL3151949 | 0.78 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL3152530 | 0.76 | CRHR1 (0.71) | CRHR1 | |
| SCHEMBL3152759 | 0.74 | CRHR1 (0.63) | CRHR1 | |
| SCHEMBL3155744 | 0.73 | CRHR1 (0.63) | CRHR1 | |
| SCHEMBL3148603 | 0.73 | CRHR1 (0.62) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420810-B2 | Bicyclic heterocyclic compound | Ono Pharmaceutical, Co., Ltd. (JP) | 2013-04-16 | — | — | US | disclosed |
| US-20100137318-A1 | BICYCLIC HETEROCYCLIC COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2010-06-03 | — | — | US | disclosed |
| EP-2154139-A1 | BICYCLIC HETEROCYCLIC COMPOUND | ONO Pharmaceutical Co., Ltd. (JP) | 2010-02-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137318-A1 | BICYCLIC HETEROCYCLIC COMPOUND | CRH, CRHR1, NR3C2 | CRHR1 2/4885KDM5B 4852/4885USP1 4456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.