Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 3/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | DRD2 | P14416 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ibopamine SCHEMBL32682197 | 1.00 | ADRB2 (1.00) | ADRB2DRD1ADRA2ADRD2ADRA2C | |
| Ibopamine SCHEMBL147258 | 1.00 | ADRB2 (1.00) | ADRB2DRD1ADRA2ADRD2ADRA2C | |
| Ibopamine SCHEMBL1412013 | 0.99 | ADRB2 (0.97) | ADRB2DRD1ADRA2ADRD2ADRA2C | |
| SCHEMBL23676962 | 0.93 | ADRB2 (0.87) | ADRB2DRD1ADRA2ADRD2ADRA2C | |
| Ibopamine SCHEMBL1411634 | 0.92 | ADRB2 (0.85) | ADRB2DRD1ADRA2ADRD2ADRA2C | |
| Ibopamine SCHEMBL1411632 | 0.92 | ADRB2 (0.85) | ADRB2DRD1ADRA2ADRD2ADRA2C | |
| Hydrochloric Acid SCHEMBL9346052 | 0.92 | ADRB2 (0.85) | ADRB2DRD1ADRA2ADRD2ADRA2C | |
| Hydrochloric Acid SCHEMBL9344074 | 0.89 | ADRB2 (0.79) | ADRB2DRD1ADRA2ADRD2ADRA2C | |
| SCHEMBL10438186 | 0.89 | ADRB2 (0.79) | ADRB2DRD1ADRA2ADRD2ADRA2C | |
| Hydrochloric Acid SCHEMBL9346080 | 0.88 | ADRB2 (0.77) | ADRB2DRD1ADRA2ADRD2ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004251-A1 | Dopamine-Agonist Combination Therapy For Improving Sleep Quality | SEPRACOR INC. (US) | 2010-01-07 | — | — | US | disclosed |
| EP-1742624-A2 | DOPAMINE-AGONIST COMBINATION THERAPY WITH SEDATIVES FOR IMPROVING SLEEP QUALITY | Sepracor, Inc. (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005079851-A2 | DOPAMINE-AGONIST COMBINATION THERAPY WITH SEDATIVES FOR IMPROVING SLEEP QUALITY | SEPRACOR, INC. (US) | 2005-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004251-A1 | Dopamine-Agonist Combination Therapy For Improving Sleep Quality | DRD2, DRD1, DRD3 | ADRB2 19/4885DRD1 2/4885ADRA2A 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.