Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 6/20 | 0.50 |
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2007262 | 0.93 | HTR1A (0.52) | HTR1ADRD4TP53MAPTHSD17B10 | |
| SCHEMBL2002301 | 0.93 | HTR1A (0.49) | GLSHTR1ADRD4TP53MAPT | |
| SCHEMBL2006828 | 0.91 | ALDH1A1 (0.49) | GLSHTR1ATP53POLB | |
| SCHEMBL2005541 | 0.88 | HTR1A (0.52) | HTR1ADRD4 | |
| SCHEMBL2002796 | 0.88 | KMT2A (0.45) | GLSHTR1ATP53POLB | |
| SCHEMBL2005080 | 0.87 | DRD4 (0.49) | HTR1ADRD4MAPTPOLB | |
| SCHEMBL4685114 | 0.84 | HTR1A (0.46) | HTR1ADRD4MAPTHSD17B10 | |
| SCHEMBL2005025 | 0.84 | HTR1A (0.54) | HTR1ADRD4MAPTHSD17B10 | |
| SCHEMBL4687884 | 0.84 | HTR1A (0.52) | HTR1ADRD4 | |
| SCHEMBL2007150 | 0.83 | POLB (0.52) | TP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981504-B1 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | REMYND NV (BE) | 2010-07-21 | — | — | EP | claimed |