SCHEMBL31444487

SCHEMBL31444487

COc1ccc(CN2C(=O)COCC2c2cccc(F)c2Cl)cc1

nearest known ligand 0.56

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HCRTR2 O43614 13/20 0.56
HCRTR1 O43613 12/20 0.56
RORC P51449 1/20 0.41
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
SLC5A1 P13866 2/20 0.40
SLC5A2 P31639 2/20 0.40
P2RX7 Q99572 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1334979 0.79 HCRTR1 (0.58) HCRTR2HCRTR1MEN1KMT2A
SCHEMBL1334981 0.79 HCRTR1 (0.58) HCRTR2HCRTR1MEN1KMT2A
SCHEMBL31444317 0.78 SLC5A2 (0.40) HCRTR2HCRTR1RORCMEN1KMT2A
SCHEMBL31444485 0.78 RORC (0.39) HCRTR2HCRTR1RORCMEN1KMT2A
SCHEMBL31444354 0.77 MEN1 (0.39) HCRTR2HCRTR1MEN1KMT2ASLC5A1
SCHEMBL31444335 0.77 SLC5A1 (0.41) HCRTR2HCRTR1RORCMEN1KMT2A
SCHEMBL25329990 0.75 HCRTR1 (0.53) HCRTR2HCRTR1MEN1KMT2A
SCHEMBL697331 0.75 HCRTR1 (0.52) HCRTR2HCRTR1MEN1KMT2A
SCHEMBL1459146 0.75 HCRTR1 (0.52) HCRTR2HCRTR1MEN1KMT2A
SCHEMBL3508819 0.75 HCRTR1 (0.52) HCRTR2HCRTR1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072451-A1 RAS-PI3K INHIBITORS FOR THE TREATMENT OF CANCER AND IMMUNOLOGICAL DISEASES VIVIDION THERAPEUTICS, INC. (US) 2025-04-03 WO disclosed