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SCHEMBL31444700

SCHEMBL31444700

CN1C(=O)Cc2cc(Nc3nc(N4CCC(CN5CCC(CNc6ccc7c(c6)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CC4)ncc3Cl)ccc21

nearest known ligand 0.47

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 12/20 0.47
▸ BTK Q06187 2/20 0.47
▸ PTK2 Q05397 1/20 0.42
▸ ALK Q9UM73 2/20 0.41
▸ PLK4 O00444 2/20 0.40
▸ AR P10275 3/20 0.40
▸ DDB1 Q16531 6/20 0.40
▸ EGFR P00533 2/20 0.39
▸ GSPT1 P15170 1/20 0.39
▸ ITK Q08881 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31595777 0.87 CRBN (0.53) CRBNBTKPTK2ALKPLK4
SCHEMBL31595385 0.83 CRBN (0.46) CRBNBTKPTK2DDB1
SCHEMBL23267690 0.83 CRBN (0.46) CRBNBTKPTK2DDB1
SCHEMBL23267722 0.79 CRBN (0.53) CRBNBTKPTK2ALKAR
SCHEMBL31595461 0.79 CRBN (0.53) CRBNBTKPTK2ALKAR
SCHEMBL31595323 0.78 CRBN (0.51) CRBNBTKPTK2ALKPLK4
SCHEMBL23267708 0.78 CRBN (0.48) CRBNBTKPTK2ALKPLK4
SCHEMBL31595625 0.78 CRBN (0.48) CRBNBTKPTK2ALKPLK4
SCHEMBL31595686 0.76 PTK2 (0.51) CRBNBTKPTK2ALKAR
SCHEMBL23267313 0.76 CRBN (0.49) CRBNBTKPTK2ALKPLK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025096710-A1 MODULATORS OF BCL6 AS LIGAND DIRECTED DEGRADERS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-05-08 — — WO disclosed
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