Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL304259 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAMAPTALDH1A1KDM4E | |
| SCHEMBL303567 | 0.67 | MAPT (0.43) | SMN1; SMN2LMNAMAPTALDH1A1KDM4E | |
| SCHEMBL304536 | 0.67 | JAK2 (0.41) | SMN1; SMN2LMNAMAPTALDH1A1KDM4E | |
| SCHEMBL3176574 | 0.63 | AKR1C3 (0.57) | SMN1; SMN2LMNAALDH1A1AKR1C3AKR1C2 | |
| SCHEMBL302187 | 0.63 | FAAH (0.47) | SMN1; SMN2LMNAMAPTALDH1A1KDM4E | |
| SCHEMBL2103706 | 0.62 | KMT2A (0.64) | SMN1; SMN2LMNAKMT2AMEN1TSHR | |
| SCHEMBL14591314 | 0.62 | ALDH1A1 (0.49) | SMN1; SMN2LMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL304024 | 0.61 | MAPT (0.43) | SMN1; SMN2LMNAMAPTALDH1A1KDM4E | |
| SCHEMBL1922152 | 0.61 | AKR1C3 (0.56) | SMN1; SMN2LMNAKMT2AMEN1TSHR | |
| SCHEMBL26517036 | 0.61 | AKR1C3 (0.56) | SMN1; SMN2LMNAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500853-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2328871-A2 | HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2011-06-08 | — | — | EP | claimed |
| WO-2010027746-A2 | HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2010-03-11 | — | — | WO | claimed |